X0407 4 2023-05-02 0 0001818331 GeneDx Holdings Corp. WGS 0001200796 PFENNIGER RICHARD C JR C/O GENEDX HOLDINGS CORP. 333 LUDLOW ST, NORTH TOWER, 6TH FLOOR STAMFORD CT 06902 1 0 0 0 0 Class A Common Stock 2023-05-02 4 M 0 30303 0.00 A 30303 D Restricted Stock Unit 2023-05-02 4 M 0 30303 0.00 D Class A Common Stock 60606 0 D Each restricted stock unit represents a contingent right to receive 1 share of the Issuer's Class A Common Stock upon settlement for no consideration. The underlying shares vest as to 1/3 of the total award annually beginning on May 2, 2023 until fully vested, subject to the Reporting Person continuing to provide services to the Issuer on the applicable vesting date. For avoidance of doubt, all numbers above are presented before giving effect to the 33:1 reverse stock split the Issuer's stockholders approved on April 14, 2023, which was previously disclosed in the Current Reports on Form 8-K filed by the Issuer on April 17, 2023 and April 28, 2023, and which shall become effective on May 4, 2023. /s/ Eunkyung Lee, Attorney-in-Fact 2023-05-04