X0306 4 2022-04-29 0 0001818331 Sema4 Holdings Corp. SMFR 0000943431 RUCH JOSHUA C/O SEMA4 HOLDINGS CORP. 333 LUDLOW ST, NORTH TOWER, 8TH FL. STAMFORD CT 06902 1 0 0 0 Class A Common Stock 2022-04-29 4 A 0 1632963 4.00 A 1632963 I By Vaal Investment Partners Q9 LP Class A Common Stock 2022-04-29 4 A 0 329665 4.00 A 329665 I By RUGU2 LLC Class A Common Stock 2022-04-29 4 A 0 162372 4.00 A 162372 I By Kariba LLC Class A Common Stock 12836 D Mr. Ruch is (i) a managing member of the managing member of the general partner of Vaal Investment Partners Q9 LP ("Q9"), (ii) a managing member of RUGU2 LLC ("RUGU2") and (iii) a managing member of Kariba LLC ("Kariba"). As such, Mr. Ruch exercises voting and investment power with respect to the shares owned by Q9, RUGU2 and Kariba. Mr. Ruch disclaims beneficial ownership of such securities, except to the extent of his pecuniary interest therein. /s/ Daniel Clark, Attorney-in-Fact 2022-07-12