X0306 4 2022-04-27 0 0001818331 Sema4 Holdings Corp. SMFR 0001585017 Ryan Jason C/O SEMA4 HOLDINGS CORP. 333 LUDLOW ST, NORTH TOWER, 8TH FL. STAMFORD CT 06902 1 0 0 0 Class A Common Stock 2022-04-27 4 M 0 12836 A 12836 D Restricted Stock Unit 2022-04-27 4 M 0 12836 0.00 D Class A Common Stock 12836 0 D Each restricted stock unit ("RSU") represents a contingent right to receive 1 share of the Issuer's Class A Common Stock upon settlement for no consideration. The RSUs will vest on the earlier of (i) the date of the next annual meeting of the Company's shareholders following the grant date and (i) the first anniversary of the grant date, in each case so long as the non-employee director continues to provide services to the Company through such vesting date. /s/ Daniel Clark, Attorney-in-Fact 2022-05-12