X0306 4 2022-05-02 0 0001818331 Sema4 Holdings Corp. SMFR 0001784705 Sherman Rachel E. C/O SEMA4 HOLDINGS CORP. 333 LUDLOW ST, NORTH TOWER, 8TH FL. STAMFORD CT 06902 1 0 0 0 Stock Option (Right to Buy) 2.155 2022-05-02 4 A 0 78914 0.00 A 2032-05-01 Class A Common Stock 78914 78914 D Restricted Stock Unit 2022-05-02 4 A 0 45454 0.00 A Class A Common Stock 45454 45454 D The underlying shares shall vest the earlier of (a) the date of the next annual meeting of the Issuer's shareholders following the grant date, and (b) the first anniversary of the grant date, subject to the Reporting Person continuing to provide services to the Issuer through each vesting date. Each restricted stock unit represents a contingent right to receive 1 share of the Issuer's Class A Common Stock upon settlement for no consideration. /s/ Daniel Clark, Attorney-in-Fact 2022-05-04