X0306 4 2022-04-19 0 0001818331 Sema4 Holdings Corp. SMFR 0001873805 Saad Kareem C/O SEMA4 HOLDINGS CORP. 333 LUDLOW ST, NORTH TOWER, 8TH FL. STAMFORD CT 06902 0 1 0 0 Chief Business Officer Class A Common Stock 2022-04-19 4 M 0 18014 A 70558 D Class A Common Stock 2022-04-20 4 S 0 6269 2.49 D 64289 D Restricted Stock Unit 2022-04-19 4 M 0 18014 0.00 D Class A Common Stock 18014 198158 D Each restricted stock unit represents a contingent right to receive 1 share of the Issuer's Class A Common Stock upon settlement for no consideration. The sales reported on this Form 4 represent shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of restricted stock units ("RSUs"). The sales were to satisfy tax withholding obligations to be funded by a "sell to cover" transaction. 3/16th of the total shares vested on October 25, 2021, 1/16th of the total shares vested on January 25, 2022, and thereafter will vest as to 1/16th of the total shares underlying the award in quarterly installments until fully vested on January 19, 2025, subject to the Reporting Person's continued service to the Issuer on each vesting date. /s/ Daniel Clark, Attorney-in-Fact 2022-04-21