X0306 4 2022-01-28 0 0001818331 Sema4 Holdings Corp. SMFR 0001873805 Saad Kareem C/O SEMA4 HOLDINGS CORP. 333 LUDLOW ST, NORTH TOWER, 8TH FL. STAMFORD CT 06902 0 1 0 0 Chief Business Officer Class A Common Stock 2022-01-28 4 S 0 6697 2.841 D 52544 D The sales reported on this Form 4 represent shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of restricted stock units ("RSUs"). The sales were to satisfy tax withholding obligations to be funded by a "sell to cover" transaction. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $2.84 to $2.88, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth herein. /s/ Daniel Clark, Attorney-in-Fact 2022-02-02