X0306 4 2021-10-01 0 0001818331 Sema4 Holdings Corp. SMFR 0001873887 Assad Shawn C/O SEMA4 HOLDINGS CORP. 333 LUDLOW ST, NORTH TOWER, 8TH FL. STAMFORD CT 06902 0 1 0 0 Chief Accounting Officer Class A Common Stock 2021-10-25 4 M 0 10457 A 10457 D Restricted Stock Unit 2021-10-25 4 M 0 10457 0.00 D Class A Common Stock 10457 156865 D Each restricted stock unit ("RSU") represents a contingent right to receive 1 share of the Issuer's Class A Common Stock upon settlement for no consideration. 1/16th of the total shares vested on October 25, 2021 and November 10, 2021, and thereafter vests as to 1/16th of the total shares underlying the award in quarterly installments until fully vested on May 10, 2025, subject to the Reporting Person's continued service to the Issuer on each vesting date. /s/ Daniel Clark, Attorney-in-Fact 2021-11-02