X0306 4 2021-10-15 0 0001818331 Sema4 Holdings Corp. SMFR 0000943431 RUCH JOSHUA C/O SEMA4 HOLDINGS CORP. 333 LUDLOW ST, NORTH TOWER, 8TH FL. STAMFORD CT 06902 1 0 0 0 Employee Stock Option (Right to Buy) 7.79 2021-10-15 4 A 0 22286 0.00 A 2031-10-14 Class A Common Stock 22286 22286 D Employee Stock Option (Right to Buy) 7.79 2021-10-15 4 A 0 22286 0.00 A 2031-10-14 Class A Common Stock 22286 22286 D Restricted Stock Unit 2021-10-15 4 A 0 12836 0.00 A Class A Common Stock 12836 12836 D Restricted Stock Unit 2021-10-15 4 A 0 12836 0.00 A Class A Common Stock 12836 12836 D The stock options and restricted stock units ("RSUs") will vest on the earlier of (i) the date of the next annual meeting of the Issuer's shareholders following the grant date and (i) the first anniversary of the grant date, in each case so long as the Reporting Person continues to provide services to the Issuer through such vesting date. The stock option shall vest as of 1/36 of the total shares monthly beginning on November 15, 2021 until fully vested, subject to the Reporting Person continuing to provide services to the Issuer through each vesting date. Each RSU represents a contingent right to receive 1 share of the Issuer's Class A Common Stock upon settlement for no consideration. The RSUs will vest in equal annual installments over the three-year period following the grant date, subject to the Reporting Person continuing to provide services to the Issuer through each vesting date. /s/ Daniel Clark, Attorney-in-Fact 2021-10-19