X0306 4 2021-10-15 0 0001818331 Sema4 Holdings Corp. SMFR 0001753655 Leproust Emily M. C/O SEMA4 HOLDINGS CORP. 333 LUDLOW STREET, NORTH TOWER, 8TH FL. STAMFORD CT 06902 1 0 0 0 Employee Stock Option (Right to Buy) 7.79 2021-10-15 4 A 0 22286 0.00 A 2031-10-14 Class A Common Stock 22286 22286 D Restricted Stock Unit 2021-10-15 4 A 0 12836 0.00 A Class A Common Stock 12836 12836 D The stock options and restricted stock units ("RSUs") will vest on the earlier of (i) the date of the next annual meeting of the Issuer's shareholders following the grant date and (i) the first anniversary of the grant date, in each case so long as the Reporting Person continues to provide services to the Issuer through such vesting date. Each RSU represents a contingent right to receive 1 share of the Issuer's Class A Common Stock upon settlement for no consideration. /s/ Daniel Clark, Attorney-in-Fact 2021-10-19