X0609 4 2026-05-07 0001818331 GeneDx Holdings Corp. WGS 0001307631 Meister Keith A. false C/O CORVEX MANAGEMENT LP 667 MADISON AVENUE NEW YORK NY 10065 true true 0001535472 Corvex Management LP false 667 MADISON AVENUE NEW YORK NY 10065 true true false Class A Common Stock 2026-05-07 4 P 0 128181 35.46 A 3356331 I See footnotes Class A Common Stock 2026-05-07 4 P 0 14786 36.33 A 3371117 I See footnotes Class A Common Stock 2026-05-07 4 P 0 123393 37.6 A 3494510 I See footnotes Class A Common Stock 2026-05-07 4 P 0 116412 38.46 A 3610922 I See footnotes Class A Common Stock 2026-05-07 4 P 0 94356 39.39 A 3705278 I See footnotes Class A Common Stock 2026-05-07 4 P 0 56630 40.46 A 3761908 I See footnotes Class A Common Stock 2026-05-08 4 P 0 15745 38 A 3777653 I See footnotes Class A Common Stock 2026-05-08 4 P 0 3396 38.7 A 3781049 I See footnotes Class A Common Stock 2026-05-08 4 P 0 79144 40.67 A 3860193 I See footnotes Class A Common Stock 2026-05-08 4 P 0 73104 41.15 A 3933297 I See footnotes Class A Common Stock 2026-05-11 4 P 0 246734 38.91 A 4180031 I See footnotes Class A Common Stock 2026-05-11 4 P 0 252734 39.65 A 4432765 I See footnotes Class A Common Stock 2026-05-11 4 P 0 532 40.35 A 4433297 I See footnotes Class A Common Stock 333144 I See footnote Class A Common Stock 20129 D The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $34.97 to $35.94. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares bought at each separate price within the ranges set forth in footnotes (1), (4), (5), (6), (7), (8), (9), (10), (11), (12), (13), (14) and (15) to this Form 4. Investment funds advised by Corvex Management LP ("Corvex") are the direct holders of 4,433,297 shares of the Class A Common Stock, par value $0.0001 per share ("Class A Common Stock") of GeneDX Holdings Corp. (the "Issuer") reported herein. Mr. Meister may be deemed to indirectly beneficially own these shares by virtue of Mr. Meister's control of the general partner of Corvex. For the purposes of this filing, each of Corvex and Mr. Meister disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein. This filing shall not be deemed an admission that Corvex or Mr. Meister is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise. The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $35.97 to $36.84. The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $37.05 to $38.04. The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $38.05 to $39.04. The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $39.05 to $40.04. The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $40.05 to $40.66. The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $37.59 to $38.58. The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $38.59 to $38.94. The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $39.95 to $40.94. The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $40.95 to $41.50. The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $38.22 to $39.21. The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $39.22 to $40.21. The price reported in Column 4 is a weighted average price. These shares were bought in multiple transactions within the range of $40.22 to $40.41. CMLS Holdings LLC ("CMLS Holdings") is the record holder of 333,144 shares of the Class A Common Stock reported herein. Mr. Meister is one of two members of the Board of Managers of CMLS Holdings, and Mr. Meister shares voting and investment discretion with respect to the securities held of record by CMLS Holdings reported herein. The shares of Class A Common Stock reflected as beneficially owned by Mr. Meister include 20,129 shares of Class A Common Stock that were issued upon the vesting of restricted stock units, that were granted to Mr. Meister in connection with his service on the board of directors of the Issuer. /s/ Keith A. Meister 2026-05-11 CORVEX MANAGEMENT LP Name: /s/ Keith Meister Title: Managing Partner 2026-05-11