SCHEDULE 13G 0002087723 XXXXXXXX LIVE Common Stock, par value $0.0001 per share 09/04/2025 0001817760 SmartKem, Inc. 83193D203 MANCHESTER TECHNOLOGY CENTER HEXAGON TOWER, DELAUNAYS ROAD, BLACKLEY MANCHESTER X0 M9 8GQ Rule 13d-1(c) Lizzio Joseph Christopher X1 239000.00 180000.00 239000.00 180000.00 419000.00 N 7.65 IN SmartKem, Inc. MANCHESTER TECHNOLOGY CENTER, HEXAGON TOWER, DELAUNAYS ROAD, BLACKLEY, MANCHESTER, UNITED KINGDOM M9 8GQ Joseph Christopher Lizzio The foregoing is referred to as a "Reporting Person". Joseph Christopher Lizzio 24 Camp Avenue P.O. Box 4836 Stamford, CT 06907 Joseph Christopher Lizzio USA Y As of September 4, 2025, Mr. Lizzio beneficially owned 419,000 shares of Common Stock. This amount includes 180,000 shares of Common Stock beneficially owned by Mr. Lizzio and his spouse jointly. The 419,000 shares of Common Stock beneficially owned by Mr. Lizzio does not include shares of Common Stock beneficially owned by the adult children of the Reporting Person. The Reporting Person does not exercise any voting power or dispositive power over the shares beneficially owned by his adult children. The following percentages are based on 5,479,787 shares of Common Stock outstanding as of September 5, 2025 based upon the Issuer's Form 8-K filed with the Securities and Exchange Commission on September 5, 2025. As of September 4, 2025, Mr. Lizzio may be deemed to beneficially own 7.65% of the outstanding shares of Common Stock, which includes 180,000 shares of Common Stock beneficially owned by Mr. Lizzio and his spouse jointly. See Cover Pages Items 5-9. See Cover Pages Items 5-9. See Cover Pages Items 5-9. See Cover Pages Items 5-9. Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Lizzio Joseph Christopher /s/ Joseph Christopher Lizzio 09/24/2025