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  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001760431</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
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    <issuerInfo>
      <issuerCik>0001817713</issuerCik>
      <issuerName>Janux Therapeutics, Inc.</issuerName>
      <secFileNumber>001-40475</secFileNumber>
      <issuerAddress>
        <com:street1>10955 VISTA SORRENTO PARKWAY</com:street1>
        <com:street2>SUITE 200</com:street2>
        <com:city>SAN DIEGO</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>92130</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(858) 751-4493</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Reardon Tighe</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Former officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Wells Fargo Clearing Services</name>
        <address>
          <com:street1>1 North Jefferson Avenue</com:street1>
          <com:city>St. Louis</com:city>
          <com:stateOrCountry>MO</com:stateOrCountry>
          <com:zipCode>63103</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>2999</noOfUnitsSold>
      <aggregateMarketValue>158909.99</aggregateMarketValue>
      <noOfUnitsOutstanding>52164498</noOfUnitsOutstanding>
      <approxSaleDate>11/01/2024</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/10/2020</acquiredDate>
      <natureOfAcquisitionTransaction>stock options</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2999</amountOfSecuritiesAcquired>
      <paymentDate>12/10/2020</paymentDate>
      <natureOfPayment>cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Tighe Reardon</name>
        <address>
          <com:street1>10955 Vista Sorrento Parkway</com:street1>
          <com:street2>Suite 200</com:street2>
          <com:city>San Diego</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Janux Therapeutics, Inc.</securitiesClassTitle>
      <saleDate>09/09/2024</saleDate>
      <amountOfSecuritiesSold>5762</amountOfSecuritiesSold>
      <grossProceeds>242707.39</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Tighe Reardpm</name>
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          <com:city>San Diego</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
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      <saleDate>09/10/2024</saleDate>
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          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
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      <saleDate>09/09/2024</saleDate>
      <amountOfSecuritiesSold>9269</amountOfSecuritiesSold>
      <grossProceeds>390690.84</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
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          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
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    <securitiesSoldInPast3Months>
      <sellerDetails>
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      <saleDate>09/12/2024</saleDate>
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      <sellerDetails>
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        <address>
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          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
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      <securitiesClassTitle>Janux Therapeutics, Inc.</securitiesClassTitle>
      <saleDate>09/12/2024</saleDate>
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      <grossProceeds>721931.94</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Tighe Reardon</name>
        <address>
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          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
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      <securitiesClassTitle>Janux Therapeutics, Inc.</securitiesClassTitle>
      <saleDate>09/27/2024</saleDate>
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      <grossProceeds>358755.10</grossProceeds>
    </securitiesSoldInPast3Months>
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      <saleDate>09/27/2024</saleDate>
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    <securitiesSoldInPast3Months>
      <sellerDetails>
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      <saleDate>09/30/2024</saleDate>
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      <grossProceeds>116802.96</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
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      <saleDate>09/30/2024</saleDate>
      <amountOfSecuritiesSold>4493</amountOfSecuritiesSold>
      <grossProceeds>209407.20</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
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          <com:stateOrCountry>CA</com:stateOrCountry>
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      <saleDate>10/16/2024</saleDate>
      <amountOfSecuritiesSold>48462</amountOfSecuritiesSold>
      <grossProceeds>2460900.36</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
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      <saleDate>10/17/2024</saleDate>
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      <grossProceeds>237605.77</grossProceeds>
    </securitiesSoldInPast3Months>
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      <sellerDetails>
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      <saleDate>10/21/2024</saleDate>
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      <grossProceeds>532152.24</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
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      <grossProceeds>317543.83</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
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          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92130</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Janux Therpeutics, Inc.</securitiesClassTitle>
      <saleDate>10/23/2024</saleDate>
      <amountOfSecuritiesSold>13039</amountOfSecuritiesSold>
      <grossProceeds>665093.96</grossProceeds>
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      <sellerDetails>
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      <saleDate>10/24/2024</saleDate>
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      <saleDate>10/28/2024</saleDate>
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      <securitiesClassTitle>Janux Therapeutics, Inc.</securitiesClassTitle>
      <saleDate>10/28/2024</saleDate>
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    </securitiesSoldInPast3Months>
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      <sellerDetails>
        <name>Tighe Reardon</name>
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      <saleDate>11/01/2024</saleDate>
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      <grossProceeds>277986.95</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>11/01/2024</noticeDate>
      <signature>Tighe Reardon</signature>
    </noticeSignature>
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