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Research Collaboration and Exclusive License Agreement with Merck - Additional Information (Detail)
$ in Millions
1 Months Ended 12 Months Ended
Aug. 31, 2025
USD ($)
Jun. 30, 2024
USD ($)
Dec. 31, 2025
USD ($)
Target
Dec. 31, 2024
USD ($)
Dec. 31, 2023
USD ($)
Merck Agreement First Collaboration Target          
Research And Development Arrangement Contract To Perform For Others [Line Items]          
Developmental milestone $ 10.0 $ 7.5      
Merck Agreement          
Research And Development Arrangement Contract To Perform For Others [Line Items]          
Number of collaboration targets | Target     2    
Non-refundable and non-creditable upfront fee     $ 8.0    
Payable upon selection of second collaboration target     8.0    
Milestone payments     285.0    
Revenue recognized     10.0 $ 10.6 $ 8.1
Merck Agreement | Maximum          
Research And Development Arrangement Contract To Perform For Others [Line Items]          
Milestone payments per collaboration target     142.5    
Milestone payments upon successful completion of certain commercial milestones     $ 350.0