Research Collaboration and Exclusive License Agreement - Additional Information (Detail) - Merck Agreement $ in Millions	3 Months Ended
	Mar. 31, 2025 USD ($) Target	Mar. 31, 2024 USD ($)
Research And Development Arrangement Contract To Perform For Others [Line Items]
Number of collaboration targets | Target	2
Non-refundable and non-creditable upfront fee	$ 8.0
Payable upon selection of second collaboration target	8.0
Milestone payments	285.0
Revenue recognized	0.0	$ 1.3
Maximum
Research And Development Arrangement Contract To Perform For Others [Line Items]
Milestone payments per collaboration target	142.5
Milestone payments upon successful completion of certain commercial milestones	$ 350.0