Research Collaboration and Exclusive License Agreement - Additional Information (Detail) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023 USD ($)	Jun. 30, 2022 USD ($)	Jun. 30, 2023 USD ($) Target	Jun. 30, 2022 USD ($)	Dec. 31, 2022 USD ($)
Research And Development Arrangement Contract To Perform For Others [Line Items]
Deferred revenue current	$ 5,340		$ 5,340		$ 5,406
Accounts receivable balance outstanding	0		$ 0		$ 0
Merck Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Number of collaboration targets | Target			2
Non-refundable and non-creditable upfront fee			$ 8,000
Payable upon selection of second collaboration target	8,000		8,000
Milestone payments			285,000
Revenue recognized	1,100	$ 2,400	3,100	$ 4,000
Deferred revenue	5,600		5,600
Deferred revenue current	$ 5,300		5,300
Merck Agreement | Maximum
Research And Development Arrangement Contract To Perform For Others [Line Items]
Milestone payments per collaboration target			142,500
Milestone payments upon successful completion of certain commercial milestones			$ 350,000