<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001741283</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0001817229</issuerCik>
            <issuerName>VOR BIOPHARMA INC.</issuerName>
            <secFileNumber>001-39979</secFileNumber>
            <issuerAddress>
                <ns2:street1>100 Cambridgepark Drive, Suite 101</ns2:street1>
                <ns2:city>Cambridge</ns2:city>
                <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                <ns2:zipCode>02140</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(617) 655-6580</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Robert Ang</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Officer</relationshipToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>214135</noOfUnitsSold>
            <aggregateMarketValue>520586.06</aggregateMarketValue>
            <noOfUnitsOutstanding>124959520</noOfUnitsOutstanding>
            <approxSaleDate>07/15/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>09/30/2019</acquiredDate>
            <natureOfAcquisitionTransaction>Exercised Shares</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>214135</amountOfSecuritiesAcquired>
            <paymentDate>09/30/2019</paymentDate>
            <natureOfPayment>Cash</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>Robert Ang</name>
                <address>
                    <ns2:street1>100 Cambridgepark Drive, Suite 101</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02140</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/10/2025</saleDate>
            <amountOfSecuritiesSold>84855</amountOfSecuritiesSold>
            <grossProceeds>197160.59</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>Robert Ang</name>
                <address>
                    <ns2:street1>100 Cambridgepark Drive, Suite 101</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02140</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/10/2025</saleDate>
            <amountOfSecuritiesSold>512030</amountOfSecuritiesSold>
            <grossProceeds>1190930.58</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT ANG</name>
                <address>
                    <ns2:street1>100 Cambridgepark Drive, Suite 101</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02140</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/02/2025</saleDate>
            <amountOfSecuritiesSold>30468</amountOfSecuritiesSold>
            <grossProceeds>54537.72</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT ANG</name>
                <address>
                    <ns2:street1>100 Cambridgepark Drive, Suite 101</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02140</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/02/2025</saleDate>
            <amountOfSecuritiesSold>14468</amountOfSecuritiesSold>
            <grossProceeds>25897.72</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT ANG</name>
                <address>
                    <ns2:street1>100 Cambridgepark Drive, Suite 101</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02140</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/01/2025</saleDate>
            <amountOfSecuritiesSold>16000</amountOfSecuritiesSold>
            <grossProceeds>27523.20</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT ANG</name>
                <address>
                    <ns2:street1>100 Cambridgepark Drive, Suite 101</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02140</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>07/01/2025</saleDate>
            <amountOfSecuritiesSold>24468</amountOfSecuritiesSold>
            <grossProceeds>42089.85</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT ANG</name>
                <address>
                    <ns2:street1>100 Cambridgepark Drive, Suite 101</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02140</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/30/2025</saleDate>
            <amountOfSecuritiesSold>5686</amountOfSecuritiesSold>
            <grossProceeds>9837.35</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT ANG</name>
                <address>
                    <ns2:street1>100 Cambridgepark Drive, Suite 101</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02140</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/30/2025</saleDate>
            <amountOfSecuritiesSold>5686</amountOfSecuritiesSold>
            <grossProceeds>9837.35</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT ANG</name>
                <address>
                    <ns2:street1>100 Cambridgepark Drive, Suite 101</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02140</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/30/2025</saleDate>
            <amountOfSecuritiesSold>5686</amountOfSecuritiesSold>
            <grossProceeds>9837.35</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT ANG</name>
                <address>
                    <ns2:street1>100 Cambridgepark Drive, Suite 101</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02140</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/30/2025</saleDate>
            <amountOfSecuritiesSold>5259</amountOfSecuritiesSold>
            <grossProceeds>9098.60</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT ANG</name>
                <address>
                    <ns2:street1>100 Cambridgepark Drive, Suite 101</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02140</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/30/2025</saleDate>
            <amountOfSecuritiesSold>6624</amountOfSecuritiesSold>
            <grossProceeds>11460.18</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT ANG</name>
                <address>
                    <ns2:street1>100 Cambridgepark Drive, Suite 101</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02140</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/30/2025</saleDate>
            <amountOfSecuritiesSold>5686</amountOfSecuritiesSold>
            <grossProceeds>9837.35</grossProceeds>
        </securitiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>ROBERT ANG</name>
                <address>
                    <ns2:street1>100 Cambridgepark Drive, Suite 101</ns2:street1>
                    <ns2:city>Cambridge</ns2:city>
                    <ns2:stateOrCountry>MA</ns2:stateOrCountry>
                    <ns2:zipCode>02140</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>06/30/2025</saleDate>
            <amountOfSecuritiesSold>6000</amountOfSecuritiesSold>
            <grossProceeds>10380.60</grossProceeds>
        </securitiesSoldInPast3Months>
        <noticeSignature>
            <noticeDate>07/15/2025</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ Robert Ang</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
