X0306 4 2023-02-06 0 0001817229 Vor Biopharma Inc. VOR 0001741283 ANG ROBERT C/O VOR BIOPHARMA INC. 100 CAMBRIDGEPARK DRIVE, SUITE 101 CAMBRIDGE MA 02140 1 1 0 0 President and CEO Common Stock 2023-02-06 4 A 0 128750 0.00 A 713322 D Employee Stock Option (right to buy) 5.55 2023-02-06 4 A 0 257500 0.00 A 2033-02-05 Common Stock 257500 257500 D Represents the number of shares underlying restricted stock units ("RSUs"). Each RSU represents the contingent right to receive one share of common stock of the Issuer. The RSUs vest over four years in equal quarterly installments beginning February 6, 2023, subject to the Reporting Person's continued service as of each such date. The shares shall vest and become exercisable in a series of 48 successive equal monthly installments beginning on February 6, 2023, in each case subject to the Reporting Person's continued service as of each such date. /s/ Rich Segal, Attorney-in-Fact 2023-02-08