X0306 4 2022-06-14 0 0001817229 Vor Biopharma Inc. VOR 0001690959 Resnick Joshua C/O VOR BIOPHARMA INC. 100 CAMBRIDGEPARK DRIVE, SUITE 101 CAMBRIDGE MA 02140 1 0 0 0 Stock Option (right to buy) 4.26 2022-06-14 4 A 0 16911 0.00 A 2032-06-13 Common Stock 16911 16911 D This option was granted to the Reporting Person pursuant to the Issuer's non-employee director compensation policy. The shares underlying the option vest and become exercisable on the earlier of (i) June 14, 2023 or (ii) the Issuer's next annual meeting of stockholders following the grant date, in each case, subject to the Reporting Person's continued service as a director through such date. /s/ Rich Segal, Attorney-in-Fact 2022-06-16