X0306 4 2021-11-16 0 0001817229 Vor Biopharma Inc. VOR 0001664281 PARMAR KUSH C/O VOR BIOPHARMA INC. 100 CAMBRIDGEPARK DRIVE, SUITE 400 CAMBRIDGE MA 02140 1 0 1 0 Common Stock 2021-11-16 4 S 0 238870 15.30 D 4595089 I See footnote Common Stock 2021-11-16 4 S 0 91836 15.30 D 1766634 I See footnote The shares are directly held by 5AM Ventures VI, L.P. 5AM Partners VI, LLC is the general partner of 5AM Ventures VI, L.P. The Reporting Person is a managing member of 5AM Partners VI, LLC, and may be deemed to share voting and dispositive power over the shares held by 5AM Ventures VI, L.P. The reporting person disclaims beneficial ownership of the reported securities, except to the extent of his pecuniary interest therein. The shares are directly held by 5AM Opportunities I, L.P. 5AM Opportunities I (GP), LLC is the general partner of 5AM Opportunities I, L.P. The Reporting Person is a managing member of 5AM Opportunities I (GP), LLC, and may be deemed to share voting and dispositive power over the shares held by 5AM Opportunities I, L.P. The reporting person disclaims beneficial ownership of the reported securities, except to the extent of his pecuniary interest therein. /s/ Kush Parmar 2021-11-18