<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001315082</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001817229</issuerCik>
      <issuerName>Vor Biopharma Inc.</issuerName>
      <secFileNumber>001-39979</secFileNumber>
      <issuerAddress>
        <com:street1>500 BOYLSTON STREET</com:street1>
        <com:street2>SUITE 1350</com:street2>
        <com:city>BOSTON</com:city>
        <com:stateOrCountry>MA</com:stateOrCountry>
        <com:zipCode>02116</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>617-655-6580</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>RA Capital Healthcare Fund LP</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
        <relationshipToIssuer>10% Stockholder</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>BTIG, LLC</name>
        <address>
          <com:street1>350 Bush Street</com:street1>
          <com:street2>9th Floor</com:street2>
          <com:city>San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94104</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>218043</noOfUnitsSold>
      <aggregateMarketValue>6323247.00</aggregateMarketValue>
      <noOfUnitsOutstanding>6841134</noOfUnitsOutstanding>
      <approxSaleDate>10/17/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ GS</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/12/2019</acquiredDate>
      <natureOfAcquisitionTransaction>Private Financing</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Vor Biopharma Inc</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>13133</amountOfSecuritiesAcquired>
      <paymentDate>02/12/2019</paymentDate>
      <natureOfPayment>Wire</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/05/2020</acquiredDate>
      <natureOfAcquisitionTransaction>Private Financing</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Vor Biopharma Inc</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6366</amountOfSecuritiesAcquired>
      <paymentDate>02/05/2020</paymentDate>
      <natureOfPayment>Wire</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/05/2020</acquiredDate>
      <natureOfAcquisitionTransaction>Private Financing</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Vor Biopharma Inc</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>35683</amountOfSecuritiesAcquired>
      <paymentDate>02/05/2020</paymentDate>
      <natureOfPayment>Wire</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>06/30/2020</acquiredDate>
      <natureOfAcquisitionTransaction>Private Financing</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Vor Biopharma Inc</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>71705</amountOfSecuritiesAcquired>
      <paymentDate>06/30/2020</paymentDate>
      <natureOfPayment>Wire</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common </securitiesClassTitle>
      <acquiredDate>06/30/2020</acquiredDate>
      <natureOfAcquisitionTransaction>Private Financing </natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Vor Biopharma Inc</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>22898</amountOfSecuritiesAcquired>
      <paymentDate>06/30/2020</paymentDate>
      <natureOfPayment>Wire</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/08/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Private Financing</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Vor Biopharma Inc	</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>11449</amountOfSecuritiesAcquired>
      <paymentDate>01/08/2021</paymentDate>
      <natureOfPayment>Wire </natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/08/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Private Financing</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Vor Biopharma Inc</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>94603</amountOfSecuritiesAcquired>
      <paymentDate>01/08/2021</paymentDate>
      <natureOfPayment>Wire</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/05/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Private Financing</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Vor Biopharma Inc</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>11449</amountOfSecuritiesAcquired>
      <paymentDate>02/05/2021</paymentDate>
      <natureOfPayment>Wire</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/05/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Private Financing</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Vor Biopharma Inc</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>64563</amountOfSecuritiesAcquired>
      <paymentDate>02/05/2021</paymentDate>
      <natureOfPayment>Wire</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/05/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Private Financing</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Vor Biopharma Inc</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>13081</amountOfSecuritiesAcquired>
      <paymentDate>02/05/2021</paymentDate>
      <natureOfPayment>Wire</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>RA Capital Healthcare Fund, L.P</name>
        <address>
          <com:street1>200 BERKELEY STREET</com:street1>
          <com:street2>18TH FLOOR</com:street2>
          <com:city>BOSTON</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02116</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>10/15/2025</saleDate>
      <amountOfSecuritiesSold>42933</amountOfSecuritiesSold>
      <grossProceeds>1311852.16</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name> RA Capital Healthcare Fund, L.P</name>
        <address>
          <com:street1>200 BERKELEY STREET, 18TH FLOOR</com:street1>
          <com:city>BOSTON</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02116</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>10/16/2025</saleDate>
      <amountOfSecuritiesSold>126887</amountOfSecuritiesSold>
      <grossProceeds>3736365.36</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>10/17/2025</noticeDate>
      <signature>David Crowe</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
