CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023
Cash flows from operating activities
Net loss	$ (116,914)	$ (117,863)
Adjustments to reconcile net loss to net cash used in operations:
Depreciation expense	3,528	3,492
Non-cash lease expense	5,041	4,727
Stock-based compensation	9,847	13,362
Interest amortization on marketable securities	(1,149)	(4,660)
Gain on sale of property and equipment	(18)
Changes in operating assets and liabilities:
Operating lease liabilities	(3,830)	(3,583)
Prepaid expenses and other current assets	(835)	3,270
Accounts payable and accrued liabilities	2,241	2,850
Other assets	2,429	(1,887)
Net cash used in operating activities	(99,660)	(100,292)
Cash flow from investing activities
Purchases of marketable securities	(9,914)	(74,923)
Proceeds from maturities of marketable securities	107,000	147,000
Purchases of property and equipment	(229)	(1,069)
Net cash provided by investing activities	96,857	71,008
Cash flow from financing activities
Proceeds from the issuance of common stock from private placement	55,550
Payment of issuance costs related to underwritten public offering and private placements	(2,325)	(717)
Proceeds from the issuance of common stock from at-the-market sales agreement, net of issuance costs	275	4,578
Repurchases of shares for tax withholdings upon vesting of restricted stock unit awards	(333)	(1,187)
Proceeds from stock option exercises and the issuance of shares under ESPP	225	264
Net cash provided by financing activities	53,392	2,938
Net increase (decrease) in cash, cash equivalents and restricted cash equivalents	50,589	(26,346)
Cash, cash equivalents and restricted cash equivalents, beginning of period	33,773	60,119
Cash, cash equivalents and restricted cash equivalents, end of period	84,362	33,773
Supplemental disclosure of non-cash activities
Purchases of property and equipment in accounts payable and accrued liabilities		70
Financing costs associated with the sale of common stock included in accounts payable and accrued expenses	$ 563	$ 27