CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
Cash flows from operating activities
Net loss	$ (91,602)	$ (68,184)
Adjustments to reconcile net loss to net cash used in operations:
Depreciation expense	2,600	1,893
Non-cash lease expense	3,513	2,451
Stock-based compensation	11,468	6,816
Interest (amortization) accretion on marketable securities	(3,674)	163
Changes in operating assets and liabilities:
Operating lease liabilities, net	(2,646)	(9,037)
Prepaid expenses and other current assets	2,558	316
Accounts payable and accrued liabilities	2,678	(542)
Other assets	(1,161)	(674)
Net cash used in operating activities	(76,266)	(66,798)
Cash flow from investing activities
Purchases of marketable securities	(58,369)	(5,044)
Proceeds from maturities of marketable securities	120,000	16,130
Purchases of property and equipment	(958)	(8,141)
Net cash provided by investing activities	60,673	2,945
Cash flow from financing activities
Payment of issuance costs related to underwritten public offering and concurrent private placement	(717)
Proceeds from the issuance of common stock from at-the-market sales agreement, net of issuance costs	4,593	4,345
Shares repurchased for tax withholdings upon vesting of restricted stock unit awards	(1,165)
Proceeds from stock option exercises and the issuance of shares under ESPP	202	534
Net cash provided by financing activities	2,913	4,879
Net decrease in cash, cash equivalents and restricted cash equivalents	(12,680)	(58,974)
Cash, cash equivalents and restricted cash equivalents, beginning of period	60,119	122,214
Cash, cash equivalents and restricted cash equivalents, end of period	47,439	63,240
Supplemental disclosure of non-cash activities
Right-of-use assets obtained in exchange for lease obligations	37	24,207
Purchases of property and equipment in accounts payable and accrued liabilities	63	$ 56
Financing costs associated with the sale of common stock included in accounts payable and accrued expenses	$ 30