CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Cash flows from operating activities
Net loss	$ (58,412)	$ (44,396)
Adjustments to reconcile net loss to net cash used in operations:
Depreciation expense	1,707	1,001
Amortization of operating lease right-of-use assets	2,317	1,311
Stock-based compensation	8,306	3,487
Interest (amortization) accretion on marketable securities	(2,447)	120
Changes in operating assets and liabilities:
Operating lease liabilities, net	(1,729)	(7,037)
Prepaid expenses and other current assets	2,214	(728)
Accounts payable and accrued liabilities	19	(1,473)
Other assets	(343)	(181)
Net cash used in operating activities	(48,368)	(47,896)
Cash flow from investing activities
Purchases of marketable securities	(58,370)	(5,044)
Proceeds from maturities of marketable securities	79,000	3,130
Purchases of property and equipment	(493)	(7,843)
Net cash provided by (used in) investing activities	20,137	(9,757)
Cash flow from financing activities
Payment of issuance costs related to underwritten public offering and concurrent private placement	(717)
Proceeds from the issuance of common stock from at-the-market sales agreement, net of issuance costs	4,201	504
Shares repurchased for tax withholdings upon vesting of restricted stock unit awards	(945)
Proceeds from stock option exercises and the issuance of shares under ESPP	198	300
Net cash provided by financing activities	2,737	804
Net decrease in cash, cash equivalents and restricted cash equivalents	(25,494)	(56,849)
Cash, cash equivalents and restricted cash equivalents, beginning of period	60,119	122,214
Cash, cash equivalents and restricted cash equivalents, end of period	34,625	65,365
Supplemental disclosure of non-cash activities
Right-of-use assets obtained in exchange for lease obligations	107	23,376
Purchases of property and equipment in accounts payable and accrued liabilities		$ 1,331
Financing costs associated with the sale of common stock included in accounts payable and accrued expenses	$ 24