CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Cash flows from operating activities
Net loss	$ (28,433)	$ (22,737)
Adjustments to reconcile net loss to net cash used in operations:
Depreciation expense	837	426
Non-cash lease expense	1,953	920
Stock-based compensation	4,068	1,746
Interest (amortization) accretion on marketable securities	(1,202)	65
Changes in operating assets and liabilities:
Operating lease liability	(1,544)	(727)
Prepaid expenses and other current assets	7	(1,740)
Accounts payable and accrued liabilities	(88)	(722)
Other assets	134	(135)
Net cash used in operating activities	(24,268)	(22,904)
Cash flow from investing activities
Purchases of marketable securities	(23,408)	(5,044)
Proceeds from maturities of marketable securities	30,000
Purchases of property and equipment	(94)	(2,011)
Net cash provided by (used in) investing activities	6,498	(7,055)
Cash flow from financing activities
Payment of issuance costs related to underwritten public offering and concurrent private placement	(717)
Proceeds from the issuance of common stock from at-the-market sales agreement, net of issuance costs	3,622
Taxes paid related to net share settlement of equity awards	(400)
Proceeds from stock option exercises	14	200
Net cash provided by financing activities	2,519	200
Net decrease in cash, cash equivalents and restricted cash equivalents	(15,251)	(29,759)
Cash, cash equivalents and restricted cash equivalents, beginning of period	60,119	122,214
Cash, cash equivalents and restricted cash equivalents, end of period	44,868	92,455
Supplemental disclosure of non-cash activities
Lease incentive paid by the landlord on behalf of the Company		1,509
Right-of-use assets obtained in exchange for lease obligations	270	6,377
Purchases of property and equipment in accounts payable and accrued liabilities	$ 3	$ 3,539