Significant Agreements - Additional Information (Details) - USD ($)	Dec. 31, 2022	Dec. 31, 2021	Nov. 30, 2021	Oct. 31, 2020
Columbia License Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
License fee obligated to pay	$ 0	$ 0
Columbia License Agreement | Maximum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Aggregate potential milestone payments upon achievement of clinical milestones			$ 200,000
Aggregate potential milestone payments upon achievement of regulatory and commercial milestones			$ 6,300,000
National Institutes of Health License Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Aggregate potential milestone payments				$ 8,000,000.0
License fee obligated to pay	$ 0	$ 0
National Institutes of Health License Agreement | Licensed Products
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Aggregate potential milestone payments				6,000,000.0
National Institutes of Health License Agreement | Maximum | Licensed Products
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Milestone payments on aggregate net sales				$ 2,000,000,000.0