X0306 4 2021-03-01 0 0001549595 Nurix Therapeutics, Inc. NRIX 0001817160 Hansen Gwenn C/O NURIX THERAPEUTICS, INC. 1700 OWENS STREET, SUITE 205 SAN FRANCISCO CA 94158 0 1 0 0 Chief Scientific Officer Common Stock 2021-03-01 4 M 0 800 7.26 A 14604 D Common Stock 2021-03-01 4 S 0 800 35.95 D 13804 D Employee Stock Option (right to buy) 7.26 2021-03-01 4 M 0 800 0.00 D 2030-02-26 Common Stock 800 75066 D This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person. Includes 1,804 shares of Common Stock acquired by the Reporting Person on February 12, 2021 pursuant to the Issuer's employee stock purchase plan. The stock option vests as to 1/48 of the total shares monthly beginning February 18, 2020 until the option is fully vested on January 18, 2024, subject to the Reporting Person's provision of service to the Issuer on each vesting date. The option contains an early-exercise provision and is exercisable as to unvested shares, subject to the Issuer's right of repurchase. /s/ Christine Ring, as Attorney-in-Fact for Gwenn Hansen 2021-03-02