X0306 4 2021-06-24 0 0001815776 Graphite Bio, Inc. GRPH 0001817033 Carlo Rizzuto C/O GRAPHITE BIO, INC. 279 EAST GRAND AVENUE, SUITE 430 SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Stock Option (right to buy) 17.00 2021-06-24 4 A 0 40000 0.00 A 2031-06-23 Common Stock 40000 40000 D 1/36th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of June 24, 2021, subject to the Reporting Person's continuous service to the Issuer on each such date. /s/ Franco Valle, attorney-in-fact 2021-06-28