144 0001778739 XXXXXXXX LIVE 0001816736 Disc Medicine, Inc. 001-39438 321 ARSENAL STREET, SUITE 101 WATERTOWN MA 02472 (617) 674-9274 White William Richard Director Common Jefferies LLC

520 Madison Ave 4th Fl New York NY 10022

9696 418479.36 29670000 08/01/2024 NASDAQ Common 09/14/2021 Exercise of Stock Options Disc Medicine, Inc. N 804 09/14/2021 N/A Common 11/17/2020 Exercise of Stock Options Disc Medicine, Inc. N 1756 11/27/2020 N/A Common 06/09/2023 Exercise of Stock Options Disc Medicine, Inc. N 7136 06/09/2023 N/A N William White

321 Arsenal Street Suite 101 Watertown MA 02472

Common 05/01/2024 201 5754.96 William White

321 Arsenal Street Suite 101 Watertown MA 02472

Common 06/03/2024 1957 70608.17 William White

321 Arsenal Street Suite 101 Watertwon MA 02472

Common 07/01/2024 201 9253.30 All sales are to be made pursuant to a previously signed/adopted 10b5-I selling plan dated 12/13/2023 and all representations regarding non-public information were made as of the adoption of the plan. 08/01/2024 12/13/2023 William White