144 0001778739 XXXXXXXX LIVE 0001816736 Disc Medicine, Inc. 001-39438 321 ARSENAL STREET, SUITE 101 WATERTOWN MA 02472 (617) 674-9274 White William Richard Director Common Jefferies LLC

520 Madison Ave 4th Fl New York NY 10022

4919 155046.88 24680000 04/11/2024 NASDAQ Common 11/27/2020 Exercise of Stock Options DISC MEDICINE, INC. N 3512 11/27/2020 N/A Common 09/14/2021 Exercise of Stock Options DISC MEDICINE, INC. N 1407 09/14/2021 N/A Y All sales are to be made pursuant to a previously signed/adopted 10b5-I selling plan dated 12/13/2023 and all representations regarding non-public information were made as of the adoption of the plan. 04/11/2024 12/13/2023 William White