144 0001951850 XXXXXXXX LIVE 0001816736 Disc Medicine, Inc. 001-39438 321 Arsenal Street,Suite101 Watertown MA 02472 6176749274 RAHUL KHARA Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

2500 175400.00 38199089 06/26/2026 NASDAQ Common 06/26/2026 Exercise of Stock Options Issuer N 2500 06/26/2026 Cash N 10b5-1 Sales for RAHUL KHARA

321 Arsenal Street,Suite101 Watertown MA 02472

Common 06/18/2026 7500 526660.50 The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 06/26/2026 03/19/2026 /s/ Rahul Khara