144 0001951849 XXXXXXXX LIVE 0001816736 Disc Medicine, Inc. 001-39438 321 Arsenal Street,Suite101 Watertown MA 02472 6176749274 JONATHAN YU Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

30000 2507400.00 37750162 11/11/2025 NASDAQ Common 11/11/2025 Exercise of Stock Options Issuer N 30000 11/11/2025 Cash Y Sales that were executed on November 11, 2025 are being reported on this Form 144 filed on November 12, 2025 given the EDGAR system was not accepting filings on November 11, 2025 in observance of the federal holiday. 11/11/2025 07/22/2025 /s/ Jonathan Yu