<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001628098</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001816736</issuerCik>
      <issuerName>Disc Medicine, Inc.</issuerName>
      <secFileNumber>001-39438</secFileNumber>
      <issuerAddress>
        <com:street1>321 ARSENAL STREET, SUITE 101</com:street1>
        <com:city>WATERTOWN</com:city>
        <com:stateOrCountry>MA</com:stateOrCountry>
        <com:zipCode>02472</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>617-674-9274</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Atlas Venture Fund X, LP</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Shareholder</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Merrill Lynch</name>
        <address>
          <com:street1>One Bryant Park</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10036</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>22666</noOfUnitsSold>
      <aggregateMarketValue>2085272</aggregateMarketValue>
      <noOfUnitsOutstanding>37750162</noOfUnitsOutstanding>
      <approxSaleDate>12/16/2025</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>05/01/2020</acquiredDate>
      <natureOfAcquisitionTransaction>Private Placement</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>22666</amountOfSecuritiesAcquired>
      <paymentDate>05/01/2020</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>See attached Table II for sales of securities over the last three months.</remarks>
    <noticeSignature>
      <noticeDate>12/16/2025</noticeDate>
      <signature>Ommer Chohan</signature>
    </noticeSignature>
  </formData>

</edgarSubmission>
