144 0001951850 XXXXXXXX LIVE 0001816736 DISC MEDICINE, INC. 001-39438 321 Arsenal Street Suite 101 Watertown MA 02472 617-674-9274 Khara Rahul Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

2853 159625.35 37750162 02/17/2026 NASDAQ Common 02/15/2026 RSU Vesting Issuer N 2853 02/15/2026 N/A N 10b5-1 Sales for RAHUL KHARA

321 Arsenal Street Suite 101 Watertown MA 02472

Common 01/02/2026 6500 511471.98 10b5-1 Sales for RAHUL KHARA

321 Arsenal Street Suite 101 Watertown MA 02472

Common 01/20/2026 1000 69740 Represents sale of shares to cover tax withholding obligations in connection with the vesting of certain restricted stock units previously granted to the Reporting Person. This sale is a "sell to cover" transaction and does not represent a discretionary transaction by the Reporting Person. 02/17/2026 /s/ Rahul Khara