<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <previousAccessionNumber>0001628280-21-002105</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001843859</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>3</amendmentNo>
      <securitiesClassTitle>Ordinary shares, nominal value GBP0.008 per share</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>12/31/2024</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001816590</issuerCik>
        <issuerName>COMPASS PATHWAYS PLC</issuerName>
        <issuerCusip>20451W101</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>33 Broadwick Street</com:street1>
          <com:city>London</com:city>
          <com:stateOrCountry>X0</com:stateOrCountry>
          <com:zipCode>W1F 0DQ</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(d)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>George Jay Goldsmith</reportingPersonName>
      <citizenshipOrOrganization>X0</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>2369156.00</soleVotingPower>
        <soleDispositivePower>2369156.00</soleDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>2369156.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>2.6</classPercent>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Ekaterina Malievskaia</reportingPersonName>
      <citizenshipOrOrganization>X0</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>2307662.00</soleVotingPower>
        <soleDispositivePower>2307662.00</soleDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>2307662.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>2.5</classPercent>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>COMPASS PATHWAYS PLC</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>33 Broadwick Street, London, X0, W1F 0DQ</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>This statement is filed by George Jay Goldsmith and Ekaterina Malievskaia.</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>Each Reporting Person's address is c/o COMPASS Pathways plc, 33 Broadwick Street, London W1F 0DQ,
United Kingdom</principalBusinessOfficeOrResidenceAddress>
        <citizenship>The Reporting Persons are citizens of the United Kingdom.</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>Mr. Goldsmith directly beneficially owns 2,369,156 Ordinary Shares, representing approximately 2.56% of the outstanding Ordinary Shares, which includes:(i) 2,179,653 Ordinary Shares and (ii) 189,503 Ordinary Shares subject to a stock option exercisable within 60 days of December 31, 2024. Dr. Malievskaia directly beneficially owns 2,307,662 Ordinary Shares, representing approximately 2.49% of the outstanding Ordinary Shares, which includes: (i) 2,176,694 Ordinary Shares and (ii) 130,968 Ordinary Shares subject to a stock option exercisable within 60 days of December 31, 2024.
Mr. Goldsmith and Dr. Malievskaia are married to each other, but each Reporting Person expressly disclaims beneficial ownership of the securities held by the other Reporting Person.
The percentage of the outstanding Ordinary Shares beneficially owned by the Reporting Person is based on 92,423,796 Ordinary Shares outstanding as of January 13, 2025, as disclosed in the Issuer's Prospectus Supplement on Form 424b(5) as filed with the Securities and Exchange Commission on January 10, 2025.</amountBeneficiallyOwned>
        <classPercent>5.04</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>Mr. Goldsmith directly beneficially owns 2,369,156 Ordinary Shares and Dr. Malievskaia directly beneficially owns 2,307,662 Ordinary Shares.</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>0</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>Mr. Goldsmith directly beneficially owns 2,369,156 Ordinary Shares and Dr. Malievskaia directly beneficially owns 2,307,662 Ordinary Shares.</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>0</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
        <classOwnership5PercentOrLess>N</classOwnership5PercentOrLess>
      </item5>
      <item6>
        <notApplicableFlag>N</notApplicableFlag>
        <ownershipMoreThan5PercentOnBehalfOfAnotherPerson>Not Applicable.</ownershipMoreThan5PercentOnBehalfOfAnotherPerson>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
      </item10>
    </items>
    <exhibitInfo>Exhibit A. Power of Attorney (1). Exhibit B. Power of Attorney (2).  (1) Power of Attorney previously filed as Exhibit 24 to a Form 4 with regard to COMPASS Pathways plc filed with the Securities and Exchange Commission on June 6, 2023 by George Jay Goldsmith. (2) Power of Attorney previously filed as Exhibit 24 to a Form 4 with regard to COMPASS Pathways plc filed with the Securities and Exchange Commission on November 2, 2023 by Ekaterina Malievskaia.</exhibitInfo>
    <signatureInformation>
      <reportingPersonName>George Jay Goldsmith</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Meredith Prithviraj by Power of Attorney for George Jay Goldsmith</signature>
        <title>Meredith Prithviraj, Power of Attorney for George Jay Goldsmith</title>
        <date>02/13/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Ekaterina Malievskaia</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Meredith Prithviraj by Power of Attorney for Ekaterina Malievskaia</signature>
        <title>Meredith Prithviraj, Power of Attorney for Ekaterina Malievskaia</title>
        <date>02/13/2025</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
</edgarSubmission>
