Consolidated Statements of Shareholders’ Equity - USD ($) $ in Thousands	Total	At-The-Market Offering	Private Investment In Public Entity Offering	ADDITIONAL PAID-IN CAPITAL	ADDITIONAL PAID-IN CAPITAL At-The-Market Offering	ADDITIONAL PAID-IN CAPITAL Private Investment In Public Entity Offering	ACCUMULATED OTHER COMPREHENSIVE LOSS	ACCUMULATED DEFICIT	ORDINARY SHARES	ORDINARY SHARES COMMON STOCK	ORDINARY SHARES COMMON STOCK At-The-Market Offering	ORDINARY SHARES COMMON STOCK Private Investment In Public Entity Offering	DEFERRED SHARES COMMON STOCK
Beginning balance (in shares) at Dec. 31, 2022										42,631,794			1
Beginning balance at Dec. 31, 2022	$ 181,280			$ 458,825			$ (16,867)	$ (261,146)		$ 440			$ 28
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of ordinary shares under ATM facility or PIPE offering, net of issuance costs (in shares)											2,937,622	16,076,750
Issuance of ordinary shares under ATM facility or PIPE offering, net of issuance costs		$ 28,120	$ 116,815		$ 28,091	$ 116,652					$ 29	$ 163
Issuance of warrants to purchase ordinary shares	687			687
Exercise of share options (in shares)									166,801	166,801
Exercise of share options	2									$ 2
Issuance of ordinary shares to settle vested restricted stock units (in shares)									69,120	78,022
Issuance of ordinary shares to settle vested restricted stock units	0			(1)						$ 1
Cancellation of deferred share (in shares)													(1)
Cancellation of deferred share	0			28									$ (28)
Issuance of ordinary shares under employee share purchase plan (in shares)										52,482
Issuance of ordinary shares under employee share purchase plan	351			351
Shares tendered for withholding taxes	(265)			(265)
Share-based compensation expense	17,277			17,277
Unrealized loss on foreign currency translation	(59)						(59)
Net loss	$ (118,464)							(118,464)
Ending balance (in shares) at Dec. 31, 2023	61,943,471									61,943,471			0
Ending balance at Dec. 31, 2023	$ 225,744			621,645			(16,926)	(379,610)		$ 635			$ 0
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of ordinary shares under ATM facility or PIPE offering, net of issuance costs (in shares)											2,509,798
Issuance of ordinary shares under ATM facility or PIPE offering, net of issuance costs		$ 26,219			$ 26,194						$ 25
Issuance of warrants to purchase ordinary shares (in shares)										3,752,050
Issuance of warrants to purchase ordinary shares	$ 37,258			37,220						$ 38
Exercise of share options (in shares)	189,214								189,214	189,214
Exercise of share options	$ 221			219						$ 2
Issuance of ordinary shares to settle vested restricted stock units (in shares)									83,527	83,527
Issuance of ordinary shares to settle vested restricted stock units	0			(1)						$ 1
Issuance of ordinary shares under employee share purchase plan (in shares)										74,155
Issuance of ordinary shares under employee share purchase plan	365			364						$ 1
Shares tendered for withholding taxes	(239)			(239)
Share-based compensation expense	19,517			19,517
Unrealized loss on foreign currency translation	732						732
Net loss	$ (155,122)							(155,122)
Ending balance (in shares) at Dec. 31, 2024	68,552,215									68,552,215			0
Ending balance at Dec. 31, 2024	$ 154,695			$ 704,919			$ (16,194)	$ (534,732)		$ 702			$ 0