Shareholders' Equity (Details)				12 Months Ended			16 Months Ended	39 Months Ended
	Aug. 18, 2023 $ / shares shares	Aug. 16, 2023 $ / shares shares	Oct. 08, 2021 USD ($)	Dec. 31, 2024 USD ($) vote shares	Dec. 31, 2023 USD ($) shares	Dec. 31, 2022 shares	Dec. 31, 2024 USD ($) shares	Dec. 31, 2024 USD ($) shares	Dec. 31, 2024 USD ($) shares	Dec. 31, 2024 £ / shares	Dec. 31, 2024 USD ($) shares	Feb. 29, 2024	Dec. 31, 2023 £ / shares	Jun. 30, 2023 USD ($) shares	Sep. 30, 2020 £ / shares	Aug. 31, 2020 £ / shares
Class of Stock [Line Items]
Cash dividend declared or paid | $				$ 0
Ordinary share conversion ratio	1		1
Exercise of share options (in shares)				189,214
Common stock, par value (in GBP per share) | £ / shares										£ 0.008			£ 0.008
Number of shares available for purchase, percent of principal amount of term loan (as a percent)											0.025
Number of options exercisable (in shares)											94,222
Fair value of exercisable options | $											$ 700,000
Proceeds from the exercise of warrants | $				$ 37,258,000	$ 0
PIPE Warrants
Class of Stock [Line Items]
Sale of stock, shares issued in transaction (in shares)							3,752,050
Term of warrants and rights outstanding											3 years 6 months	3 years
Proceeds from the exercise of warrants | $				$ 37,300,000			$ 37,300,000
Hercules Capital, Inc.
Class of Stock [Line Items]
Number of shares available for purchase, percent of principal amount of term loan (as a percent)														0.025
Term of warrants and rights outstanding														10 years
Number of options exercisable (in shares)														94,222
Fair value of exercisable options | $														$ 700,000
Employee Stock Purchase Plan
Class of Stock [Line Items]
Shares issued under employee share purchase plans (in shares)				74,155	52,482
At-The-Market Offering
Class of Stock [Line Items]
Sale of stock, shares issued in transaction (in shares)								5,491,836	5,491,836
Consideration received on transaction | $								$ 54,800,000	$ 54,800,000
Private Placement
Class of Stock [Line Items]
Ordinary share conversion ratio		1
Sale of stock, shares issued in transaction (in shares)	16,076,750	16,076,750		3,752,050
Purchase price (in dollars per share) | $ / shares	$ 9.93	$ 9.93
Private Placement | PIPE Warrants
Class of Stock [Line Items]
Term of warrants and rights outstanding												3 years
Ordinary shares
Class of Stock [Line Items]
Number of votes | vote				1
Exercise of share options (in shares)				189,214	166,801
Vested (in shares)				107,644	96,177
Issuance of ordinary shares to settle vested restricted stock units (in shares)				83,527	69,120
Shares settled during period (in shares)				24,117	27,057
Restricted share units vested (in shares)					78,022
Vested (in shares)						8,902
Common stock, par value (in GBP per share) | £ / shares										0.008			0.008		£ 0.008	£ 0.001
American Depositary Shares | Initial Public Offering
Class of Stock [Line Items]
Amount of stock authorized | $			$ 150,000,000
DEFERRED SHARES
Class of Stock [Line Items]
Common stock, par value (in GBP per share) | £ / shares										£ 21,921.504			£ 21,921.504		£ 21,921.504