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Share-based Compensation - Share Options (Details) - USD ($)
$ / shares in Units, $ in Thousands
12 Months Ended 24 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2022
Number of Shares              
Granted (in shares)       2,120,783 1,043,702    
Exercised (in shares)       (462,722) (1,244,709)    
Cancelled or forfeited (in shares)       (480,832) (313,830)    
Outstanding, ending balance (in shares) 5,092,732     5,092,732     5,092,732
Weighted Average Exercise Price              
Outstanding, beginning balance (in dollars per share)       $ 13.53 $ 5.61   $ 5.61
Granted (in dollars per share)       13.49 36.11    
Exercised (in dollars per share)       0.75 1.55    
Forfeited (in dollars per share)       11.09 22.45    
Outstanding, ending balance (in dollars per share) $ 13.55 $ 13.53 $ 5.61 $ 13.55 $ 13.53 $ 5.61 $ 13.55
Weighted Average Remaining Contractual Term (Years) and Aggregate Intrinsic Value              
Outstanding balance (in years) 8 years 4 months 17 days 8 years 7 months 20 days 9 years 2 months 19 days        
Exercisable (in years) 7 years 8 months 1 day            
Unvested (in years) 8 years 11 months 26 days            
Outstanding, aggregate intrinsic value $ 13,013 $ 51,162 $ 186,426 $ 13,013 $ 51,162 $ 186,426 $ 13,013
Aggregate intrinsic value of options exercised during the period       $ 5,500 $ 47,400 $ 12,800  
Weighted Average Grant Date Fair Value, Granted (in dollars per share)       $ 10 $ 21.35 $ 9.83  
Unrecognized compensation cost of options $ 30,400 $ 27,400 $ 18,100 $ 30,400 $ 27,400 $ 18,100 $ 30,400
Research and development              
Number of Shares              
Exercisable (in shares) 2,342,389     2,342,389     2,342,389
Weighted Average Exercise Price              
Exercisable (in dollars per share) $ 9.14     $ 9.14     $ 9.14
Weighted Average Remaining Contractual Term (Years) and Aggregate Intrinsic Value              
Exercisable, aggregate intrinsic value $ 11,765     $ 11,765     $ 11,765
General and administrative              
Number of Shares              
Unvested (in shares) 2,750,343     2,750,343     2,750,343
Weighted Average Exercise Price              
Unvested (in dollars per share) $ 17.31     $ 17.31     $ 17.31
Weighted Average Remaining Contractual Term (Years) and Aggregate Intrinsic Value              
Unvested, aggregate intrinsic value $ 1,247     $ 1,247     $ 1,247
Ordinary shares              
Number of Shares              
Exercised (in shares)       (462,722)      
Vested restricted share units, for which shares are not in issue              
Weighted Average Remaining Contractual Term (Years) and Aggregate Intrinsic Value              
Period for recognition (in years)       2 years 9 months 18 days 3 years 1 month 6 days 3 years 6 months  
Vested restricted share units, for which shares are not in issue | Ordinary shares              
Number of Shares              
Outstanding, beginning balance (in shares)       3,915,503 4,430,340   4,430,340
Outstanding, ending balance (in shares)   3,915,503 4,430,340   3,915,503 4,430,340