Net Loss Per Share

12 Months Ended

Dec. 31, 2022

Basic and diluted net loss per share attributable to ordinary shareholders was calculated as follows (in thousands, except share and per share amounts):


	Year Ended December 31,
	2022		2021		2020
Numerator
Net loss	$	(91,505)	$	(71,742)	$	(60,334)
Net loss attributable to ordinary shareholders - basic and diluted	$	(91,505)	$	(71,742)	$	(60,334)

Denominator
Weighted-average number of ordinary shares used in net loss per share - basic and diluted	42,436,292		39,997,587		16,991,664
Net loss per share - basic and diluted	$	(2.16)	$	(1.79)	$	(3.55)

The Company’s potentially dilutive securities, which include unvested ordinary shares, unvested restricted share units, and options granted, have been excluded from the computation of diluted net loss per share as the effect would be to reduce the net loss per share. Therefore, the weighted-average number of ordinary shares outstanding used to calculate both basic and diluted net loss per share attributable to ordinary shareholders is the same. The Company excluded the following potential ordinary shares, presented based on amounts outstanding at each period end, from the computation of diluted net loss per share attributable to ordinary shareholders for the years ended December 31, 2022, 2021 and 2020 because including them would have had an anti-dilutive effect:


	Year Ended December 31,
	2022	2021	2020
Unvested restricted share units	271,135	115,140	217,482
Unvested ordinary shares	—	—	13,757
Vested restricted share units, for which shares are not in issue	17,888	57,875	—
Share options	5,092,732	3,915,503	4,430,340
	5,381,755	4,088,518	4,661,579