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Share-Based Compensation - 2017 Equity Incentive Plan (Details)
$ in Thousands
6 Months Ended 12 Months Ended 24 Months Ended
Sep. 22, 2020
USD ($)
shares
May 19, 2020
shares
Jun. 30, 2020
Dec. 31, 2021
USD ($)
day
shares
Dec. 31, 2020
USD ($)
shares
Dec. 31, 2019
USD ($)
Aug. 17, 2020
USD ($)
shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Number of shares available for grant       406,737      
Share-based compensation expense | $       $ 8,639 $ 17,983 $ 3,253  
Research and Development Expense              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Share-based compensation expense | $       4,569 6,336 1,817  
General and Administrative Expense              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Share-based compensation expense | $       $ 4,070 $ 11,647 $ 1,436  
2017 Equity Incentive Plan              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Number of shares available for grant       514,075      
Vesting of restricted stock units (in shares)       12,607      
Restricted share units vested (in shares)       70,482      
2017 Equity Incentive Plan | President and Chief Business Officer              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Granted (in shares)   1,015,813          
Vested (in shares)             1,015,813
Ordinary Shares              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Granted (in shares)       0 0    
Vested (in shares)       13,757 1,829,786    
Ordinary Shares | 2017 Equity Incentive Plan              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Number of shares authorized       13,601,246      
Share options              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Share-based compensation expense | $ $ 3,500            
Options vested due to accelerated vesting (in shares) 866,268            
Share options | Research and Development Expense              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Share-based compensation expense | $ $ 1,400            
Share options | General and Administrative Expense              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Share-based compensation expense | $ $ 2,100            
Share options | 2017 Equity Incentive Plan              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Share-based compensation expense | $             $ 9,500
Expiration period       10 years      
Share options | 2017 Equity Incentive Plan | Research and Development Expense              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Share-based compensation expense | $             2,400
Share options | 2017 Equity Incentive Plan | General and Administrative Expense              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Share-based compensation expense | $             $ 7,100
Share options | 2017 Equity Incentive Plan | Options Granted Before June 30, 2020              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Award vesting period       1 year      
Award vesting percentage       25.00%      
Vesting percentage if listed on a stock exchange       100.00%      
Share options | 2017 Equity Incentive Plan | Share-based Payment Arrangement, Tranche One              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Award vesting percentage       33.30%      
Share options | 2017 Equity Incentive Plan | Share-based Payment Arrangement, Tranche One | Grant Date June 30, 2020              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Award vesting period       1 year      
Award vesting percentage       25.00%      
Share options | 2017 Equity Incentive Plan | Share-based Payment Arrangement, Tranche Two | Grant Date June 30, 2020              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Award vesting period       3 years      
Award vesting percentage       75.00%      
Share options | 2017 Equity Incentive Plan | Minimum              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Award vesting period       3 years      
Share options | 2017 Equity Incentive Plan | Maximum              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Award vesting period       4 years      
Vested restricted share units for which shares are not in issue | 2017 Equity Incentive Plan              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Award vesting period       4 years      
Award vesting percentage       25.00%      
Vested restricted share units for which shares are not in issue | 2017 Equity Incentive Plan | Share-based Payment Arrangement, Tranche One | Grant Date June 30, 2020              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Award vesting percentage       25.00%      
Expiration period     1 year        
Percentage amount closing price is higher than listing price       20.00%      
Threshold consecutive trading days | day       5