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Share-Based Compensation - Narrative (Details)
$ / shares in Units, $ in Thousands
12 Months Ended 24 Months Ended
Sep. 22, 2020
USD ($)
shares
May 19, 2020
shares
Aug. 17, 2018
Aug. 17, 2017
Dec. 31, 2020
USD ($)
day
$ / shares
shares
Dec. 31, 2020
USD ($)
£ / shares
shares
Dec. 31, 2019
USD ($)
$ / shares
shares
Aug. 17, 2020
USD ($)
shares
Sep. 30, 2020
shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Share-based compensation expense         $ 17,983   $ 3,253    
Exercise of share options (in shares) | shares         429,929        
Exercise of share options         $ 0        
Weighted average grant date fair value of shares granted (in dollars per share) | $ / shares         $ 9.83   $ 1.88    
Unrecognized compensation cost of options         $ 18,100 $ 18,100      
Research and Development Expense                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Share-based compensation expense         6,336   $ 1,817    
General and Administrative Expense                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Share-based compensation expense         $ 11,647   $ 1,436    
United Kingdom Employee                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Weighted average exercise price (in dollars per share) | $ / shares         $ 4.04   $ 0.01    
United States Employee                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Weighted average exercise price (in dollars per share) | $ / shares         $ 4.77   $ 1.39    
Certain Optionees                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Exercise of share options (in shares) | shares         232,227        
Exercise of share options         $ 100        
Share-based Payment Arrangement, Tranche One | Ordinary Shares                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Award vesting percentage       25.00%          
Share-based Payment Arrangement, Tranche Two | Ordinary Shares                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Award vesting percentage     25.00%            
Ordinary Shares                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Granted (in shares) | shares         0        
Vested (in shares) | shares         1,829,786        
Weighted average grant date fair value of shares granted (in dollars per share) | $ / shares         $ 0        
Share options                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Share-based compensation expense $ 3,500                
Options vested due to accelerated vesting (in shares) | shares 866,268                
Period for recognition         3 years 6 months        
Share options | Research and Development Expense                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Share-based compensation expense $ 1,400                
Share options | General and Administrative Expense                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Share-based compensation expense $ 2,100                
Share options | Ordinary Shares                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Granted (in shares) | shares         3,405,490   1,539,411    
Restricted Share Units (RSUs)                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Unrecognized compensation cost         $ 2,000 $ 2,000      
Period for recognition         3 years 2 months 12 days        
Exercise price (in pound sterling per share) | £ / shares           $ 0.01      
Restricted Shares                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Unrecognized compensation cost         $ 100 $ 100      
Period for recognition         4 months 24 days        
Vested in period, fair value         $ 1,300   $ 1,700    
2017 Equity Incentive Plan | President and Chief Business Officer                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Granted (in shares) | shares   1,015,813              
Vested (in shares) | shares               1,015,813  
2017 Equity Incentive Plan | Ordinary Shares                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Number of shares authorized | shares         13,601,246 13,601,246      
Number of shares available for issuance | shares         440,207 440,207      
2017 Equity Incentive Plan | Share options                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Share-based compensation expense               $ 9,500  
Expiration period         10 years        
2017 Equity Incentive Plan | Share options | Research and Development Expense                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Share-based compensation expense               2,400  
2017 Equity Incentive Plan | Share options | General and Administrative Expense                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Share-based compensation expense               $ 7,100  
2017 Equity Incentive Plan | Share options | Share-based Payment Arrangement, Tranche One                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Award vesting percentage         33.30%        
2017 Equity Incentive Plan | Share options | Share-based Payment Arrangement, Tranche Two                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Award vesting percentage         25.00%        
2017 Equity Incentive Plan | Share options | Options Granted Before June 30, 2020                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Award vesting percentage         100.00%        
2017 Equity Incentive Plan | Share options | Minimum                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Award vesting period         3 years        
2017 Equity Incentive Plan | Share options | Maximum                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Award vesting period         4 years        
2017 Equity Incentive Plan | Restricted Share Units (RSUs)                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Award vesting period         4 years        
Award vesting percentage         25.00%        
2017 Equity Incentive Plan | Restricted Share Units (RSUs) | Share-based Payment Arrangement, Tranche One                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Award vesting percentage         25.00%        
Percentage amount closing price is higher than listing price         20.00%        
Threshold consecutive trading days | day         5        
2020 Share Option Plan | Ordinary Shares                  
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                  
Shares reserved for future issuance | shares         2,074,325 2,074,325     2,074,325
Maximum percentage of shares outstanding number of shares reserved for issuance may increase                 4.00%
Number of shares available for grant | shares         1,178,547 1,178,547