Exhibit 32.1

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Annual Report on Form 10-K of Ouster, Inc. (the “Company”) for the period ended

December 31, 2022 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I

certify, pursuant to 18 U.S.C. § 1350, as adopted pursuant to § 906 of the Sarbanes-Oxley Act of 2002, that:

(1) The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act
of 1934; and

(2) The information contained in the Report fairly presents, in all material respects, the financial condition and
results of operations of the Company.

Date: March 24, 2023	By:	/s/Angus Pacala
		Angus Pacala
		Co-Founder and Chief Executive Officer (principal executive officer)