X0306 4 2021-02-01 0 0001787400 Nkarta, Inc. NKTX 0001816549 Trager James C/O NKARTA, INC. 6000 SHORELINE COURT, SUITE 102 SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Scientific Officer Common Stock 2021-02-01 4 M 0 2250 3.89 A 50672 D Common Stock 2021-02-01 4 S 0 2034 38.07 D 48638 D Common Stock 2021-02-01 4 S 0 1566 39.46 D 47072 D Common Stock 2021-02-02 4 M 0 2800 18.00 A 49872 D Common Stock 2021-02-02 4 S 0 2800 40.00 D 47072 D Stock Option (right to buy) 3.89 2021-02-01 4 M 0 2250 0.00 D 2029-09-05 Common Stock 2250 59912 D Stock Option (right to buy) 18.00 2021-02-02 4 M 0 2800 0.00 D 2030-07-08 Common Stock 2800 79600 D The transactions reported in this Form 4 were effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the reporting person at least 90 days prior to the trading date. This transaction was executed in multiple trades at prices ranging from $37.71 to $38.52. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $39.00 to $39.65. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This option originally covered 62,162 shares of NKTX common stock and was scheduled to vest and become exercisable in 48 equal monthly installments occurring on the completion of each successive month of the Reporting Person's service to the Issuer following September 5, 2019. This option originally covered 82,400 shares of NKTX common stock and was scheduled to vest and become exercisable in 48 equal monthly installments occurring on the completion of each successive month of the Reporting Person's service to the Issuer following July 9, 2020. /s/ Alicia Hager, as attorney-in-fact 2021-02-03