<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2022-10-10</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001816431</issuerCik>
        <issuerName>Quantum-Si Inc</issuerName>
        <issuerTradingSymbol>QSI</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001505034</rptOwnerCik>
            <rptOwnerName>Hawkins Jeffrey Alan</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O QUANTUM-SI INCORPORATED</rptOwnerStreet1>
            <rptOwnerStreet2>530 OLD WHITFIELD STREET</rptOwnerStreet2>
            <rptOwnerCity>GUILFORD</rptOwnerCity>
            <rptOwnerState>CT</rptOwnerState>
            <rptOwnerZipCode>06437</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>true</isOfficer>
            <officerTitle>Chief Executive Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <remarks>Exhibit 24.1 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Christian LaPointe, Ph.D., Attorney-in-Fact</signatureName>
        <signatureDate>2022-10-13</signatureDate>
    </ownerSignature>
</ownershipDocument>
