89BIO INC COM 282559103 20004194 2037087 SH SOLE 2037087 0 0 AARDVARK THERAPEUTICS INC COM 002942100 3877631 286807 SH SOLE 286807 0 0 ABEONA THERAPEUTICS INC COM NEW 00289Y206 5213661 917898 SH SOLE 917898 0 0 AKERO THERAPEUTICS INC COM 00973Y108 38088955 713811 SH SOLE 713811 0 0 AKERO THERAPEUTICS INC CALL 00973Y908 1334000 25000 SH Call SOLE 25000 0 0 ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 14938875 86552 SH SOLE 86552 0 0 AVIDITY BIOSCIENCES INC COM 05370A108 11644000 410000 SH SOLE 410000 0 0 BENITEC BIOPHARMA INC COM NEW 08205P209 2962838 253234 SH SOLE 253234 0 0 BIODESIX INC COM 09075X108 302058 1070367 SH SOLE 1070367 0 0 CAPRICOR THERAPEUTICS INC PUT 14070B959 1436871 144700 SH Put SOLE 144700 0 0 CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 4038274 198441 SH SOLE 198441 0 0 CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100 65700 5000 SH SOLE 5000 0 0 CERUS CORP COM 157085101 3508490 2488291 SH SOLE 2488291 0 0 CG ONCOLOGY INC COM 156944100 14066884 541034 SH SOLE 541034 0 0 CIDARA THERAPEUTICS INC COM NEW 171757206 5063064 103943 SH SOLE 103943 0 0 COGENT COMMUNICATIONS HLDGS CALL 19239V902 3590000 500000 SH Call SOLE 500000 0 0 COMPASS THERAPEUTICS INC COM 20454B104 3249431 1249781 SH SOLE 1249781 0 0 COMPUGEN LTD ORD M25722105 5400305 3033879 SH SOLE 3033879 0 0 DELCATH SYS INC COM NEW 24661P807 1401154 103026 SH SOLE 103026 0 0 DIANTHUS THERAPEUTICS INC COM 252828108 1784866 95806 SH SOLE 95806 0 0 ELUTIA INC CL A COM 05479K106 5468134 2761684 SH SOLE 2761684 0 0 ENLIVEN THERAPEUTICS INC COM 29337E102 200600 10000 SH SOLE 10000 0 0 ERASCA INC COM 29479A108 3263381 2569591 SH SOLE 2569591 0 0 FRACTYL HEALTH INC COM 35168W103 328196 202590 SH SOLE 202590 0 0 GOSSAMER BIO INC COM 38341P102 6330542 5146782 SH SOLE 5146782 0 0 HELIX ACQUISITION CORP II CL A ORD SHS G4444H101 6514234 613393 SH SOLE 613393 0 0 HIMS & HERS HEALTH INC PUT 433000956 2492500 50000 SH Put SOLE 50000 0 0 INSMED INC COM PAR $.01 457669307 25065398 249060 SH SOLE 249060 0 0 KALVISTA PHARMACEUTICALS INC COM 483497103 20712693 1832171 SH SOLE 1832171 0 0 KINIKSA PHARMACEUTICALS INTL ORD SHS CL A G52694109 2101786 75959 SH SOLE 75959 0 0 KODIAK SCIENCES INC COM 50015M109 1497744 401540 SH SOLE 401540 0 0 MERSANA THERAPEUTICS INC COM 59045L106 926013 3128421 SH SOLE 3128421 0 0 MERUS N V COM N5749R100 39027727 741972 SH SOLE 741972 0 0 MERUS N V CALL N5749R900 20119500 382500 SH Call SOLE 382500 0 0 METSERA INC COM 59267L107 5905679 207581 SH SOLE 207581 0 0 MINERALYS THERAPEUTICS INC COM 603170101 1559765 115282 SH SOLE 115282 0 0 MODULAR MED INC COM NEW 60785L207 529220 710363 SH SOLE 710363 0 0 MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104 3871486 82023 SH SOLE 82023 0 0 NEKTAR THERAPEUTICS COM NEW 640268306 8941 346 SH SOLE 346 0 0 NEUROCRINE BIOSCIENCES INC COM 64125C109 20483574 162969 SH SOLE 162969 0 0 NUVALENT INC COM 670703107 17974983 235583 SH SOLE 235583 0 0 NUVALENT INC CALL 670703907 7645260 100200 SH Call SOLE 100200 0 0 ORIC PHARMACEUTICALS INC COM 68622P109 18278414 1800829 SH SOLE 1800829 0 0 ORUKA THERAPEUTICS INC COM 687604108 1854011 165389 SH SOLE 165389 0 0 PFIZER INC COM 717081103 8346753 344338 SH SOLE 344338 0 0 PRAXIS PRECISION MEDICINES I COM NEW 74006W207 420500 10000 SH SOLE 10000 0 0 RADIOPHARM THERANOSTICS LTD SPONSORED ADS 75041J101 869564 187406 SH SOLE 187406 0 0 RHYTHM PHARMACEUTICALS INC COM 76243J105 25324783 400772 SH SOLE 400772 0 0 ROCKET PHARMACEUTICALS INC *W EXP 09/02/202 77313F114 3019 104828 SH SOLE 104828 0 0 SAGIMET BIOSCIENCES INC COM SER A 786700104 286047 37539 SH SOLE 37539 0 0 SCHOLAR ROCK HLDG CORP COM 80706P103 12078574 341010 SH SOLE 341010 0 0 SIONNA THERAPEUTICS INC COM 829401108 3227360 186015 SH SOLE 186015 0 0 SOLENO THERAPEUTICS INC COM 834203309 17140634 204591 SH SOLE 204591 0 0 SPDR SERIES TRUST CALL 78464A900 16586000 200000 SH Call SOLE 200000 0 0 STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106 3642691 175636 SH SOLE 175636 0 0 SYNDAX PHARMACEUTICALS INC COM 87164F105 3773758 402964 SH SOLE 402964 0 0 SYNDAX PHARMACEUTICALS INC CALL 87164F905 468000 50000 SH Call SOLE 50000 0 0 TELA BIO INC COM 872381108 5392802 2779795 SH SOLE 2779795 0 0 TOURMALINE BIO INC COM 89157D105 1747019 109257 SH SOLE 109257 0 0 TREVI THERAPEUTICS INC COM 89532M101 2951541 539587 SH SOLE 539587 0 0 UNIQURE NV SHS N90064101 2823756 202565 SH SOLE 202565 0 0 UROGEN PHARMA LTD COM M96088105 27708003 2022482 SH SOLE 2022482 0 0 VAXCYTE INC COM 92243G108 9356248 287796 SH SOLE 287796 0 0 VERACYTE INC COM 92337F107 12122820 448495 SH SOLE 448495 0 0 VERONA PHARMA PLC SPONSORED ADS 925050106 33887730 358297 SH SOLE 358297 0 0