<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2021-04-07</periodOfReport>

    <issuer>
        <issuerCik>0001375195</issuerCik>
        <issuerName>CORETEC GROUP INC.</issuerName>
        <issuerTradingSymbol>CRTG</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001815956</rptOwnerCik>
            <rptOwnerName>Hoffman Matthew Leo</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O THE CORETEC GROUP INC.</rptOwnerStreet1>
            <rptOwnerStreet2>333 JACKSON PLAZA, SUITE 1200</rptOwnerStreet2>
            <rptOwnerCity>ANN ARBOR,</rptOwnerCity>
            <rptOwnerState>MI</rptOwnerState>
            <rptOwnerZipCode>48103</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOfficer>1</isOfficer>
            <officerTitle>Chief Financial Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.15</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2021-04-07</value>
                <footnoteId id="F1"/>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>2000000</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2021-04-07</value>
            </exerciseDate>
            <expirationDate>
                <value>2026-04-07</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>2000000</value>
                    <footnoteId id="F1"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>2000000</value>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">On April 7, 2021, by way of a resolution of the board of directors of The Coretec Group, Inc. (the &quot;Company&quot;), Mr. Hoffman (the &quot;Reporting Person&quot;) was issued an option to purchase 2,000,000 shares of the Company's common stock, par value $0.0002 per share (the &quot;Common Stock&quot;) at an exercise price of $0.15 per share.</footnote>
        <footnote id="F2">Does not include options held by the Reporting Person to purchase 1,000,000 shares of Common Stock, which options are subject to a vesting schedule.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Matthew Hoffman</signatureName>
        <signatureDate>2021-04-08</signatureDate>
    </ownerSignature>
</ownershipDocument>
