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Significant Agreements - Additional Information (Details)
1 Months Ended 3 Months Ended 12 Months Ended
Dec. 16, 2021
USD ($)
ft²
Jun. 18, 2021
shares
Jun. 07, 2021
USD ($)
Apr. 30, 2021
USD ($)
Jan. 31, 2021
USD ($)
shares
Dec. 31, 2020
USD ($)
shares
Mar. 31, 2022
USD ($)
shares
Mar. 31, 2021
USD ($)
shares
Dec. 31, 2021
USD ($)
shares
Dec. 31, 2020
USD ($)
shares
May 07, 2021
shares
Research And Development Arrangement Contract To Perform For Others [Line Items]                      
Common stock, shares, issued | shares             58,010,823   58,010,823    
Research and development             $ 18,246,000 $ 5,377,000      
General and administrative             7,712,000 $ 3,991,000      
Share-based compensation arrangement exercised | shares               918,825      
Future minimum lease payments             11,030,000        
Operating lease liability             10,178,000        
Common Stock                      
Research And Development Arrangement Contract To Perform For Others [Line Items]                      
Share-based compensation arrangement exercised | shares               918,825      
Stanford Exclusive License Agreement                      
Research And Development Arrangement Contract To Perform For Others [Line Items]                      
Upfront license fees received           $ 50,000.0          
Common stock, shares, issued | shares           600,000       600,000 640,861
Common stock additional paid in capital           $ 2,800,000       $ 2,800,000  
Purchase of shares in private financings percentage           10.00%          
Shares repurchased | shares   624,845                  
Research and development                   2,800,000  
General and administrative                   200,000  
First commercial sale                   50,000.0  
Subsequent year commercial sale                   200,000.0  
Maximum future development and regulatory milestones payments             5,300,000        
Sale-based milestones payments             7,500,000        
Milestone payments             $ 0   $ 0    
Stanford Exclusive License Agreement | First Year                      
Research And Development Arrangement Contract To Perform For Others [Line Items]                      
Annual maintenance fees                   5,000.0  
Stanford Exclusive License Agreement | Second Year                      
Research And Development Arrangement Contract To Perform For Others [Line Items]                      
Annual maintenance fees                   10,000.0  
Stanford Exclusive License Agreement | Third Year                      
Research And Development Arrangement Contract To Perform For Others [Line Items]                      
Annual maintenance fees                   10,000.0  
Stanford Exclusive License Agreement | Fourth Year                      
Research And Development Arrangement Contract To Perform For Others [Line Items]                      
Annual maintenance fees                   25,000.0  
Stanford Exclusive License Agreement | Fifth Year                      
Research And Development Arrangement Contract To Perform For Others [Line Items]                      
Annual maintenance fees                   25,000.0  
Stanford Exclusive License Agreement | Sixth Year                      
Research And Development Arrangement Contract To Perform For Others [Line Items]                      
Annual maintenance fees                   $ 25,000.0  
License Agreement with Stanford | Common Stock                      
Research And Development Arrangement Contract To Perform For Others [Line Items]                      
Shares repurchased | shares   624,845                  
First Option Agreement                      
Research And Development Arrangement Contract To Perform For Others [Line Items]                      
Common stock, shares, issued | shares         132,137            
License execution fee         $ 10,000.0            
Option agreement expiration term         18 months            
Share-based compensation arrangement exercised | shares             0        
Option agreement fees paid             $ 0        
Second Option Agreement                      
Research And Development Arrangement Contract To Perform For Others [Line Items]                      
Share-based compensation arrangement exercised | shares             0        
Option agreement fees paid             $ 0        
Options fee       $ 30,000.0              
LCGM Service Agreement                      
Research And Development Arrangement Contract To Perform For Others [Line Items]                      
Research and development             1,500,000        
IDT License Agreement                      
Research And Development Arrangement Contract To Perform For Others [Line Items]                      
Research and development             0        
Milestone payments             0        
Exercise fee     $ 500,000                
Upfront payment     3,000,000.0                
Milestones probable             0        
IDT License Agreement | Research and Development Expenses                      
Research And Development Arrangement Contract To Perform For Others [Line Items]                      
Total consideration                 3,000,000.0    
IDT License Agreement | Maximum                      
Research And Development Arrangement Contract To Perform For Others [Line Items]                      
Upfront payment     5,300,000                
IDT License Agreement | Beta Thalassemia and Lysosomal Storage Disorders Fields                      
Research And Development Arrangement Contract To Perform For Others [Line Items]                      
Exercise fee     1,000,000.0                
Upfront payment     $ 8,800,000                
Bayside Lease                      
Research And Development Arrangement Contract To Perform For Others [Line Items]                      
Office and Laboratory Space | ft² 85,165                    
Lease commencement date Sep. 15, 2023                    
Lease term 120 months                    
Future minimum lease payments $ 81,000,000.0                    
Term of contract 10 years                    
Security Deposit             1,600,000   1,600,000    
Operating lease liability             $ 0   $ 0