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Significant Agreements - Additional Information (Details)				1 Months Ended				12 Months Ended
	Dec. 16, 2021 USD ($) ft²	Jun. 18, 2021 shares	Jun. 07, 2021 USD ($)	Apr. 30, 2021 USD ($)	Jan. 31, 2021 USD ($) shares	Dec. 31, 2020 USD ($) shares	Apr. 30, 2020	Dec. 31, 2021 USD ($) shares	Dec. 31, 2020 USD ($) shares	May 07, 2021 shares
Research And Development Arrangement Contract To Perform For Others [Line Items]
Common stock, shares, issued \| shares						10,279,102		58,010,823	10,279,102
Research and development								$ 37,932,000	$ 9,123,000
General and administrative								22,511,000	$ 4,377,000
Future minimum lease payments								12,346,000
Lessee, Operating Lease, Existence of Option to Extend [true false]							true
Operating lease right-of-use assets								11,574,000
Operating Lease, Liability								$ 11,276,000
Common Stock
Research And Development Arrangement Contract To Perform For Others [Line Items]
Share-based compensation arrangement exercised \| shares								33,906
Stanford Exclusive License Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Upfront license fees received						$ 50,000.0
Common stock, shares, issued \| shares						640,861			640,861	640,861
Common stock additional paid in capital						$ 2,800,000			$ 2,800,000
Purchase of shares in private financings percentage						10.00%
Shares repurchased \| shares		624,845
Research and development									2,800,000
General and administrative									200,000
First commercial sale									50,000.0
Subsequent year commercial sale									200,000.0
Maximum future development and regulatory milestone payments									5,300,000
Sale-based milestone payments									7,500,000
Milestone payments								$ 0	0
Stanford Exclusive License Agreement \| First Year
Research And Development Arrangement Contract To Perform For Others [Line Items]
Annual maintenance fees									5,000.0
Stanford Exclusive License Agreement \| Second Year
Research And Development Arrangement Contract To Perform For Others [Line Items]
Annual maintenance fees									10,000.0
Stanford Exclusive License Agreement \| Third Year
Research And Development Arrangement Contract To Perform For Others [Line Items]
Annual maintenance fees									10,000.0
Stanford Exclusive License Agreement \| Fourth Year
Research And Development Arrangement Contract To Perform For Others [Line Items]
Annual maintenance fees									25,000.0
Stanford Exclusive License Agreement \| Fifth Year
Research And Development Arrangement Contract To Perform For Others [Line Items]
Annual maintenance fees									25,000.0
Stanford Exclusive License Agreement \| Sixth Year
Research And Development Arrangement Contract To Perform For Others [Line Items]
Annual maintenance fees									$ 25,000.0
License Agreement with Stanford \| Common Stock
Research And Development Arrangement Contract To Perform For Others [Line Items]
Shares repurchased \| shares		624,845						624,845
First Option Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Common stock, shares, issued \| shares					132,137
License execution fee					$ 10,000.0
Option agreement expiration term					18 months
Share-based compensation arrangement exercised \| shares								0
Option agreement fees paid								$ 0
Second Option Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Share-based compensation arrangement exercised \| shares								0
Option agreement fees paid				$ 0
Options fee				$ 30,000.0
LCGM Service Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Research and development								$ 2,700,000
IDT License Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Research and development								3,000,000.0
Milestone payments								0
Exercise Fee			$ 500,000
Upfront payment			3,000,000.0
Milestones probable								0
IDT License Agreement \| Research and Development Expenses
Research And Development Arrangement Contract To Perform For Others [Line Items]
Total consideration								3,000,000.0
IDT License Agreement \| Maximum
Research And Development Arrangement Contract To Perform For Others [Line Items]
Upfront payment			5,300,000
IDT License Agreement \| Beta Thalassemia and Lysosomal Storage Disorders Fields
Research And Development Arrangement Contract To Perform For Others [Line Items]
Exercise Fee			1,000,000.0
Upfront payment			$ 8,800,000
Bayside Lease
Research And Development Arrangement Contract To Perform For Others [Line Items]
Lease commencement date	Sep. 15, 2023
Office and Laboratory Space \| ft²	85,165
Lease term	120 months
Security deposit								1,600,000
Future minimum lease payments	$ 81,000,000.0
Term of contract	10 years
Lessee, operating lease, option to extend	one-time option to extend for an additional ten years
Lessee, Operating Lease, Existence of Option to Extend [true false]	true
Operating lease right-of-use assets								0
Operating Lease, Liability								$ 0