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Significant Agreements - Additional Information (Details)				1 Months Ended				12 Months Ended
	Dec. 16, 2021 USD ($) ft²	Jun. 18, 2021 shares	Jun. 07, 2021 USD ($)	Apr. 30, 2021 USD ($)	Jan. 31, 2021 USD ($) shares	Dec. 31, 2020 USD ($) shares	Apr. 30, 2020	Dec. 31, 2022 USD ($) shares	Dec. 31, 2021 USD ($) shares	Dec. 31, 2020 USD ($) shares	May 07, 2021 shares
Research And Development Arrangement Contract To Perform For Others [Line Items]
Common stock, shares, issued \| shares								58,221,760	58,221,760
Research and development								$ 72,787,000	$ 37,932,000
General and administrative								32,852,000	22,511,000
Future minimum lease payments								6,174,000
Lessee, Operating Lease, Existence of Option to Extend [true false]							true
Operating lease right-of-use assets								5,580,000	$ 11,574,000
Operating Lease, Liability								$ 5,794,000
Common Stock
Research And Development Arrangement Contract To Perform For Others [Line Items]
Share-based compensation arrangement exercised \| shares								67,196	33,906
Stanford Exclusive License Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Upfront license fees received						$ 50,000.0
Common stock, shares, issued \| shares						640,861				640,861	640,861
Common stock additional paid in capital						$ 2,800,000				$ 2,800,000
Purchase of shares in private financings percentage						10.00%
Shares repurchased \| shares		624,845
Research and development										2,800,000
General and administrative										200,000
First commercial sale										50,000.0
Subsequent year commercial sale										200,000.0
Maximum future development and regulatory milestone payments								$ 5,300,000
Sale-based milestone payments								7,500,000
Milestone payments								0	$ 0
Stanford Exclusive License Agreement \| First Year
Research And Development Arrangement Contract To Perform For Others [Line Items]
Annual maintenance fees										5,000.0
Stanford Exclusive License Agreement \| Second Year
Research And Development Arrangement Contract To Perform For Others [Line Items]
Annual maintenance fees										10,000.0
Stanford Exclusive License Agreement \| Third Year
Research And Development Arrangement Contract To Perform For Others [Line Items]
Annual maintenance fees										10,000.0
Stanford Exclusive License Agreement \| Fourth Year
Research And Development Arrangement Contract To Perform For Others [Line Items]
Annual maintenance fees										25,000.0
Stanford Exclusive License Agreement \| Fifth Year
Research And Development Arrangement Contract To Perform For Others [Line Items]
Annual maintenance fees										25,000.0
Stanford Exclusive License Agreement \| Sixth Year
Research And Development Arrangement Contract To Perform For Others [Line Items]
Annual maintenance fees										$ 25,000.0
License Agreement with Stanford \| Common Stock
Research And Development Arrangement Contract To Perform For Others [Line Items]
Shares repurchased \| shares		624,845							(624,845)
First Option Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Common stock, shares, issued \| shares					132,137
License execution fee					$ 10,000.0
Share-based compensation arrangement exercised \| shares									0
Second Option Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Annual maintenance fees								10,000.0
Share-based compensation arrangement exercised \| shares									0
Options fee				$ 30,000.0
LCGM Service Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Research and development								6,100,000	$ 2,700,000
IDT License Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Research and development								0.0	3,000,000.0
Milestone payments								0	0
Exercise Fee			$ 500,000
Upfront payment			3,000,000.0
Milestones probable								0	0
IDT License Agreement \| Research and Development Expenses
Research And Development Arrangement Contract To Perform For Others [Line Items]
Total consideration									3,000,000.0
IDT License Agreement \| Maximum
Research And Development Arrangement Contract To Perform For Others [Line Items]
Upfront payment			5,300,000
IDT License Agreement \| Beta Thalassemia and Lysosomal Storage Disorders Fields
Research And Development Arrangement Contract To Perform For Others [Line Items]
Exercise Fee			1,000,000.0
Upfront payment			$ 8,800,000
Bayside Lease
Research And Development Arrangement Contract To Perform For Others [Line Items]
Tenant improvement allowance								14,900,000
Lease commencement date	Sep. 15, 2023
Office and Laboratory Space \| ft²	85,165
Lease term	120 months
Security deposit								1,600,000	1,600,000
Future minimum lease payments	$ 81,000,000.0
Term of contract	10 years
Lessee, Operating Lease, Existence of Option to Extend [true false]	true
Operating lease right-of-use assets								$ 0
Operating Lease, Liability									$ 0