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Significant Agreements - Additional Information (Details)				1 Months Ended			3 Months Ended			6 Months Ended		12 Months Ended
	Dec. 16, 2021 USD ($) ft²	Jun. 18, 2021 shares	Jun. 07, 2021 USD ($)	Apr. 30, 2021 USD ($)	Jan. 31, 2021 USD ($) shares	Dec. 31, 2020 USD ($) shares	Jun. 30, 2022 USD ($) shares	Jun. 30, 2021 USD ($) shares	Mar. 31, 2021 shares	Jun. 30, 2022 USD ($) shares	Jun. 30, 2021 USD ($) shares	Dec. 31, 2021 USD ($) shares	Dec. 31, 2020 USD ($) shares	May 07, 2021 shares
Research And Development Arrangement Contract To Perform For Others [Line Items]
Common stock, shares, issued \| shares							58,211,192			58,211,192		58,010,823
Research and development							$ 17,777,000	$ 12,667,000		$ 36,023,000	$ 18,044,000
General and administrative							8,999,000	$ 4,866,000		16,711,000	$ 8,857,000
Common stock issued upon exercise of options \| shares								3,383			922,208
Future minimum lease payments							8,854,000			8,854,000
Operating lease liability							$ 8,188,000			8,188,000
Common Stock
Research And Development Arrangement Contract To Perform For Others [Line Items]
Common stock issued upon exercise of options \| shares							43,945	3,383	918,825
Stanford Exclusive License Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Upfront license fees received						$ 50,000.0
Common stock, shares, issued \| shares						600,000							600,000	640,861
Common stock additional paid in capital						$ 2,800,000							$ 2,800,000
Purchase of shares in private financings percentage						10.00%
Shares repurchased \| shares		624,845
Research and development													2,800,000
General and administrative													200,000
First commercial sale													50,000.0
Subsequent year commercial sale													200,000.0
Maximum future development and regulatory milestones payments										5,300,000
Sale-based milestones payments										7,500,000
Milestone payments										0		$ 0
Stanford Exclusive License Agreement \| First Year
Research And Development Arrangement Contract To Perform For Others [Line Items]
Annual maintenance fees													5,000.0
Stanford Exclusive License Agreement \| Second Year
Research And Development Arrangement Contract To Perform For Others [Line Items]
Annual maintenance fees													10,000.0
Stanford Exclusive License Agreement \| Third Year
Research And Development Arrangement Contract To Perform For Others [Line Items]
Annual maintenance fees													10,000.0
Stanford Exclusive License Agreement \| Fourth Year
Research And Development Arrangement Contract To Perform For Others [Line Items]
Annual maintenance fees													25,000.0
Stanford Exclusive License Agreement \| Fifth Year
Research And Development Arrangement Contract To Perform For Others [Line Items]
Annual maintenance fees													25,000.0
Stanford Exclusive License Agreement \| Sixth Year
Research And Development Arrangement Contract To Perform For Others [Line Items]
Annual maintenance fees													$ 25,000.0
License Agreement with Stanford \| Common Stock
Research And Development Arrangement Contract To Perform For Others [Line Items]
Shares repurchased \| shares		624,845						624,845
First Option Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Common stock, shares, issued \| shares					132,137
License execution fee					$ 10,000.0
Option agreement expiration term					18 months
Second Option Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Annual maintenance fees							$ 10,000.0			$ 10,000.0
Common stock issued upon exercise of options \| shares										0
Option agreement fees paid										$ 0
Options fee				$ 30,000.0
LCGM Service Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Research and development							1.3			2.8
IDT License Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Research and development							0			0
Milestone payments							0			0
Exercise fee			$ 500,000
Upfront payment			3,000,000.0
Milestones probable							0			0
IDT License Agreement \| Research and Development Expenses
Research And Development Arrangement Contract To Perform For Others [Line Items]
Total consideration												3,000,000.0
IDT License Agreement \| Maximum
Research And Development Arrangement Contract To Perform For Others [Line Items]
Upfront payment			5,300,000
IDT License Agreement \| Beta Thalassemia and Lysosomal Storage Disorders Fields
Research And Development Arrangement Contract To Perform For Others [Line Items]
Exercise fee			1,000,000.0
Upfront payment			$ 8,800,000
Bayside Lease
Research And Development Arrangement Contract To Perform For Others [Line Items]
Office and Laboratory Space \| ft²	85,165
Lease commencement date	Sep. 15, 2023
Lease term	120 months
Future minimum lease payments	$ 81,000,000.0
Term of contract	10 years
Security Deposit							1,600,000			1,600,000		1,600,000
Operating lease liability							$ 0			$ 0		$ 0