X0508 4 2025-02-20 0001080014 Innoviva, Inc. INVA 0001815707 Basso Stephen 1350 OLD BAYSHORE HIGHWAY, SUITE 400 BURLINGAME CA 94010 true Chief Financial Officer false Common Stock 2024-11-15 4 A 0 843 0 A 12939 D Common Stock 2025-02-20 4 F 0 1106 18.07 D 11833 D Includes 843 shares of common stock acquired under the Innoviva, Inc. Employee Stock Purchase Plan on November 15, 2024. The shares were withheld by the Issuer to satisfy income tax withholding obligations associated with the quarterly vesting of previously granted employee equity grants. /s/ Stephen Basso 2025-02-24